A review of patients with acute pancreatitis treated in this hospital in recent 10 years was made.To determine the risk factors of septic necrosis in and around the pancreas,32 cases with septic necrosis which were proved in surgical operation and 44 cases without septic necrosis(as control)were included in this study.The possible factors were comparatively analysed.The results showed that septic necrosis in and around the pancreas obviously related to the diagnostic or therapeutic punctures,early surgical drainage and paralytic ileus(OR 302-548,P<005),but there were no associations with age,etiology,shock,respiratory failure and total parenteral nutrition(OR 078-126,P>005).The authers suggest that either pancreatic,peripancreatic puncture or early surgical drainage should be limited and any medication which makes paralytic ileus deteriorated such as atropine should be avoided in the treatment of acute pancreatitis.