In the acute hemorrhagic necrotizing pancreatitis(AHNP)model of rats induced by 5% sodium taurocholate,after treated with low dose dopamine〔5μg/(kg·min)〕,the alternations of mean arterial pressure,pancreatic microflow,serum amylase and lipase,and pancreatic pathohistology were studied.The results showed that low dose dopamine could increase pancreatic microflow significantly while mean arterial pressure remained stable in the early stage of AHNP,it could also reduce the levels of serum amylase and lipase,and ameliorate the pathologic severity of pancreatitis.These suggest that low dose dopamine could be used to treat pancreatitis by improving pancreatic microflow.