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find Keyword "125I 粒子" 2 results
  • 手术切除联合术中125Ⅰ粒子组织间植入治疗食管癌的疗效分析

    目的 探讨手术切除联合术中125I 粒子组织间植入治疗食管癌的疗效和副作用。 方法 回顾性分析2004 年10 月至2009 年9 月61 例中、晚期食管癌患者(盐城市第五人民医院32 例,南京医科大学附属南京第一医院29 例)采用手术切除联合术中125I 粒子组织间植入或联合放疗治疗的临床资料。根据治疗方法不同,将61 例患者分为两组,125I 粒子植入组:31 例[男21 例,女10 例;年龄(59.5±1.5)岁],采用手术切除+术中125I 粒子组织间植入治疗;对照组:30 例[男19 例,女11 例;年龄(60.1±1.6)岁],术后3 ~ 4 周采用体外放射治疗。观察两组患者术前、术后白细胞(WBC)、血小板(PLT)、免疫球蛋白的变化,比较生存率、复发率和转移率。 结果 术后1 个月、3 个月和5 个月,两组患者外周血WBC、PLT 和免疫球蛋白均在正常范围内;两组间比较差异无统计学意义(P > 0.05)。两组患者均获随访,随访时间1 ~ 5 年。术后6 个月125I 粒子植入组患者行胸部X 线片检查示:均未发现粒子移位。125I 粒子植入组患者1 年、3 年和5 年生存率均明显高于对照组(3 年58.3% vs. 42.8%,P < 0.05; 5 年36.8% vs.26.6%,P < 0.05),复发率(3 年0 % vs. 6.7%,P < 0.05; 5 年3.2% vs. 13.3%, P < 0.05)和转移率(3 年12.9%vs. 20.0%,P < 0.05; 5 年16.1% vs. 33.3%,P < 0.05)明显低于对照组。 结论 手术切除结合125I 粒子组织间植入治疗食管癌,方法简单、使用安全、副作用小,可提高食管癌患者的生存率。

    Release date:2016-08-30 05:48 Export PDF Favorites Scan
  • Experimental Study on Iodine-125 Interstitial Brachytherapy in Breast Cancer

    Objective To investigate the effect of iodine-125 on inhibiting breast cancer growth and to explore its possible mechanism. Methods The animal model of the MCF-7 tumor was established firstly through injection of the cells into nude mice. The animals were divided into two groups before the implantation of the iodine-125 granule into the tumor mass: control group (n=40, to implant no-load seeds, non-iodine-125 radioelement) and experimental group 〔n=40, to implant iodine-125 seeds (1.48×107 Bq) when the length of tumor was 8-10 mm〕. The width and length of tumor, in order to calculate the volume, were measured every three days to observe tumor growth curve and to calculate the rate of the tumor inhibition. When the length of tumor was 15-20 mm in the control group, 30 nude mice were killed in every group to detect the weight of tumor and histopathological changes. Other ten nude mice of each group were remained to be observed the national life span and survival rate for 90 days. Results Within 90 days, the average survival time in control group and experimental group were significantly different (56.2 d vs. 74.8 d, P<0.05). In control group the growth curve was continuously elevated, while experimental group showed a low flat curve. With iodine-125 treatment, the tumor growth decreased in experimental group with tumor inhibition rate 55.21%. The average tumor weight in control group and experimental group was (3.26±0.39) g and (1.46±0.17) g (t′=22.8962, P<0.05). As compared with control group, under light microscope, the number of cancer cells was less, nuclear debris increased, and cancer structure was not obvious in experimental group. Conclusion This study suggests that iodine-125 seed may inhibit the growth of breast cancer, which may be involved in direct radiation breakdown of tumor cells or induction of apoptosis and inhabitation of tumor angiogenesis.

    Release date:2016-09-08 11:05 Export PDF Favorites Scan
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