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find Keyword "A disintegrin and metalloproteinase with thrombospondin motif" 1 results
  • RESEARCH PROGRESS OF A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIF 4 AND 5 IN OSTEOARTHRITIS

    Objective To review the progress of a disintegrin and metalloproteinase with thrombospondin motif 4 (ADAMTS-4) and ADAMTS-5 in osteoarthritis. Methods Recent literature about the ADAMTS-4 and -5 in osteoarthritis was analyzed; the structure, function, inhibitors of the ADAMTS-4 and -5, and the relationship between the proteases and osteoarthritis were analyzed and summarized. Results ADAMTS-4 and -5 can reduce chondrocyte and extracellular matrix by degrading aggrecan and cartilage oligomeric matrix protein, which induced the pathogenesis of osteoarthritis. Conclusion ADAMTS-4 and -5 have been demonstrated to play important roles in osteoarthritis. It can better guide treatment and prevention of osteoarthritis to further study related mechanism of ADAMTS-4 and -5, and to promote the establishment of a clinical drug targets.

    Release date:2016-08-31 04:12 Export PDF Favorites Scan
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