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  • Influence of chronic alcohol intake on acute lung injury in rats

    Objective To investigate the influence of chronic alcohol ingestion on the severity of acute lung injury (ALI) induced by oleic acid and lipopolysaccharide (LPS).Methods Thirty-two SD rats were randomly administrated with alcohol or water for 6 weeks,then instilled with oleic acid and LPS to induce ALI or with normal saline as control.Thus the rats were randomly divided into two injury groups [ethanol group and water group] and two control groups [ethanol group and water group] (n=8 in each group). PaO2,Wet to dry lung weight ratio (W/D),levels of γ-glutamylcysteinylglycine (GSH) and malonaldehyde (MDA) in the lung tissue were measured.Results Compared to corresponding control groups,the PaO2 and GSH significantly decreased,and the lung W/D and MDA level were significantly increased in the injury groups (all Plt;0.05).In the injury groups,the changes of above parameters were more significant in the alcohol group than thoe in the water group (all Plt;0.05),except the lung W/D with no significant difference.Conclusion Chronic ethanol ingestion was relevalent to oxidation/ antioxidation imbalance and more severe lung injury in rats with severe septic after trauma,which suggests that chronic alcohol abuse could increase the severity of acute lung injury.

    Release date:2016-08-30 11:35 Export PDF Favorites Scan
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