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find Keyword "CA125" 5 results
  • Diagnostic Value of the Combined Test of Serum CA153, CA125 and CEA in Detection of Breast Cancer: A Meta-analysis

    ObjectiveTo systematically review the diagnostic value of the combined test of serum CA153, CA125 and CEA in detection of breast cancer. MethodsClinical diagnostic tests about CA153, CA125 and CEA in patients with breast cancer were retrieved in PubMed, EMbase, CBM, The Cochrane Library (Issue 3, 2014), CNKI, VIP, and WanFang Data from January 1st, 2004 to April 16st, 2014. References of included literature were also retrieved. Literature screening according to the inclusion and exclusion criteria, data extraction and methodological quality assessment were completed by two reviewers independently. Meta-analysis was then conducted using Meta-Disc 1.4 software. ResultsA total of 21 studies involving 4 263 subjects were enrolled. In all studies, the results of meta-analysis indicated that:the DOR, AUC and Q index of the single test (CA153) were 18.71 (95%CI 11.62 to 30.11), 0.858 9, and 0.789 7; while those of the combined test (CA153, CA125 and CEA) were 37.95 (95%CI 21.97 to 65.57), 0.959 1, 0.903 1. Compared with the single test, the diagnostic efficacy of the combined test was higher (Z=3.675, P=0.001 5). ConclusionCompared with the detection of CA153 alone, the combined detection of CA125, CA153 and CEA has higher efficacy and accuracy in the diagnosis of breast cancer.

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  • Detection of Serum Osteopontin, CA125 and CA199 in Patients with Endometriosis and its Signficances

    【摘要】目的探讨骨桥蛋白(OPN)联合血清CA125和CA199水平对子宫内膜异位症的诊断价值。方法2005年1月2008年12月采集45例子宫内膜异位症患者及45名健康妇女自愿捐赠的血清样品,分别采用ELISA法及化学发光法检测OPN、CA125、CA199水平。结果与健康妇女相比,子宫内膜异位症患者血清OPN和CA125、CA199含量明显升高(Plt;001)。重度组(美国生育学会分期Ⅲ、Ⅴ期)子宫内膜异位症患者OPN和CA125、CA199明显高于轻度组(Ⅰ、Ⅱ期)(Plt;001)。结论OPN、CA199可作为子宫内膜异位症诊断及病情监测的临床指标,联合CA125检测可提高其临床应用价值。

    Release date:2016-09-08 09:31 Export PDF Favorites Scan
  • 卵巢癌诊断中联合检测CA125、 CEA、CA19-9的实验研究

    【摘要】 目的 了解肿瘤标记物CA125、CEA、CA19-9联合检测提高卵巢癌诊断的敏感性。 方法 对2005年3月-2008年6月收治的58例确诊卵巢癌患者、50例正常人血清进行CA125、 CEA、CA19-9 3项肿瘤标记物的电化学发光免疫检测。 结果 CA125、CEA、CA19-9单项检测的敏感度分别为79.3%、9.4%和25.9%,3项联合检测并联试验可提高试验的敏感度至86.2%,漏诊率降至 13.8%。 结论 肿瘤标记物CA125、CEA、CA19-9联合检测可以提高恶性卵巢癌诊断的灵敏度和降低漏诊率,为卵巢肿瘤的早期诊断和治疗提供更可靠的实验依据。

    Release date:2016-09-08 09:51 Export PDF Favorites Scan
  • Significance of Detection of CA153, CA125, and CA19-9 in Diagnosis of Breast Cancer

    目的探讨血清CA153、CA125和CA19-9检测对乳腺癌早期诊断的价值。方法采用化学发光免疫法分别检测乳腺癌、乳腺良性疾病患者及正常健康体检者血清CA153、CA125和CA19-9的水平。结果乳腺癌患者血清的CA153、CA125和CA19-9的表达水平及表达阳性率均明显高于正常对照者和乳腺良性疾病患者(Plt;0.01); 乳腺癌患者术后CA153、CA125及CA19-9表达水平较术前明显下降(Plt;0.01),与正常对照者比较差异无统计学意义(Pgt;0.05)。结论肿瘤标志物CA153、CA125及CA19-9 对乳腺癌有一定的诊断价值,且可作为监测乳腺癌病情进展、评估治疗疗效及预后的指标。

    Release date:2016-09-08 10:42 Export PDF Favorites Scan
  • 黏蛋白1与卵巢癌关系的研究进展

    卵巢癌是女性生殖系统的第二大恶性肿瘤,在各类女性生殖系统恶性肿瘤中病死率居于首位。黏蛋白(MUC)1是近年来引起广泛关注的用于诊断早期卵巢癌的标志物之一。研究发现,MUC可以充当细胞表面受体和传感器,传递信号刺激细胞反应,如细胞增生、分化和凋亡,异常的MUC表达提示卵巢癌的发生和发展。MUC在卵巢上皮性肿瘤是潜在的肿瘤标志物,在卵巢癌的诊断、治疗及预后判断中可能发挥重要作用。MUC1为一种膜结合型MUC,目前关于MUC1和卵巢癌的研究较多,现就MUC1与卵巢癌关系研究进展进行综述。

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