摘要:目的: 从医学博士研究生SCI论文产出情况分析导师队伍建设中的问题,为改革医学博士研究生教育提供依据。 方法 :以某临床附属医院2003年～2008年毕业的医学科学学位博士研究生发表SCI论文情况及导师情况为研究对象,进行定量与定性分析。 结果 :导师所属学科水平、科研经费、国外教育背景及科研管理工作等方面均对博士生SCI论文的产出有影响。 结论 :增强导师队伍的科研能力和管理责任是完善导师队伍建设的方向。Abstract: Objective: To found the questions of tutor construction on the basis of SCI dissertation of PhD postgraduate and provide the evidence for transforming the medical doctor education.〖WTHZ〗Methods :Quantitative and qualitative analysis was done on the basis of the condition of the tutor and the publication of SCI paper of PhD postgraduates from 2003 to 2008 in second clinical Medical college of Beijing University. Results : The factors affecting the publication of SCI paper of PhD postgraduate included academic level、research fund、abroad ducation background and reseach management of the teacher. Conclusion : The reseach capability and management duty of the tutor must be strengthened to improve the construction of the tutor.
Objective To observe the dynamic histopathologic changes of acute rejection in rat orthotopic liver transplantation (OLT) model after tacrolimus discontinued and provide some prediction and evaluation data for clinical acute rejection after liver transplantation. Methods Kamada two-cuff technique was used to establish 60 rat OLT model， and male DA rats, male Lewis rats were used as donors and recipients respectively. Therapeutic amount of tacrolimus (0.05 mg/kg, twice per day, continued for 8 d, 1 d before operation and 7 d after operation, intragastric administrated) was administrated to recipients, then continuously half dose was decreased every day beginning from day 8 after operation and tacrolimus administration was stopped on day 13. Liver tissues were collected on day 7, 14, 21, and 28 after liver transplantation. Histopathologic changes and rejection activity index (RAI) of liver tissues were observed, survival time of recipients was calculated. Results Owing to protection effects of tacrolimus, liver tissues displayed no significant histopathologic changes of acute rejection in 7 d after OLT, while typical acute rejection histopathologic changes began to be observed on day 14 after OLT due to tacrolimus discontinuation. On day 14, 21, and 28, RAI were 3.7±0.9, 6.3±0.9, and 8.1±0.7 respectively. Survival time of recipients was (20.85±0.71) d with a median of 21 d. Conclusion Acute rejection could be induced in rat OLT model after tacrolimus discontinuation, and data collected from this model shows some extent of predictive value and assessment value for clinical liver acute rejection.