目的:观察外伤性肾损伤出血行肾动脉栓塞术及护理效果。方法:本组26例,其中12例有失血性休克。均采用Seldinger技术,经股动脉穿刺选择性肾动脉造影,超选择性插管后注入栓塞剂。术前重点监测生命体征,及时补液、止血、输血防治休克。术中顺应医师的操作,观察生命体征、小便量、色的变化。术后:重点预防穿刺点出血,观察下肢血液循环,处理疼痛,发热等并发症。结果:26例患者临床症状很快缓解,血压均在12h内恢复正常,血尿在1~2天消失,有效率达100%。结论:外伤性肾损伤出血,采用肾动脉栓塞术即可立刻止血,又可为患者保全功能正常的肾脏。
目的 探讨修正创伤评分(RTS)、CRAMS评分及院前伤情评分(PHI)对于群体伤患者死亡的评估作用。 方法 回顾性分析2011年8月-2012年8月就诊且记录完整的45例群体伤患者的病历资料,根据病历记录计算RTS、CRAMS及PHI评分,并记录患者是否死亡。绘制受试者工作特征曲线并计算出曲线下面积;根据约登指数筛选出各个评分适宜的截断值,据此计算3种创伤评分的灵敏度、特异度、阳性似然比、阴性似然比、阳性预测值、阴性预测值并进行比较。将患者按照性别、年龄分为亚组进行对比分析。 结果 RTS曲线下面积最大,且与参考线下面积对比差异有统计学意义(P=0.016),与另外两种评分比较其差异有统计学意义。 结论 RTS较CRAMS及PHI评分对于群体伤患者死亡预测具有更高的价值。
Objective To evaluate the effect of hemoperfusion for absorption of inflammatory cytokines on sepsis . Method A prospective randomized controlled study was carried out to collect 60 sepsis patients admitted to the Department of Critical Care Medicine of this hospital from June 2019 to December 2021. They were randomly divided into a study group (30 cases) and a control group (30 cases) by using the random number table method. Both groups of patients received routine treatment according to the guidelines, including fluid resuscitation, mechanical ventilation, antibiotic and vasoactive agents. For the patients with renal failure, renal replacement therapy (RRT) was used. Routine vital sign monitoring and serum procalcitonin (PCT) and interleukin-6 (IL-6) determination were recorded. The study group received two times of hemoperfusion to absorb inflammatory cytokines at 0 h and 24 h after enrollment. At 24 h and 48 h after treatment, the vital signs and related physical and chemical indexes of patients were recorded again, including norepinephrine dose, oxygenation index, PCT, IL-6 and blood lactic acid. The changes of physical and chemical indexes and the 28-day survival rate of the two groups were compared. Results There was no difference in the general situation of the two groups when they were enrolled (P>0.05). The dosage of norepinephrine [(0.77±0.48)μg·kg–1·min–1 vs. (0.92±0.62) μg·kg–1·min–1, P=0.030] and the level of blood lactic acid [(2.70±1.43)mmol/L vs. (4.05±2.60)mmol/L, P=0.001] in the study group were significantly lower than those in the control group 24 h and 48 h after treatment. The oxygenation index in the study group was higher than that of the control group 24 h after treatment (212±68)mm Hg vs. (197±42)mm Hg, P=0.042). The inflammation related indexes PCT [(17±24)ng/mL vs. (32±36)ng/mL, P=0.013] and IL-6 [299 (102, 853)pg/mL vs. 937 (247, 2230)pg/mL, P=0.026] in the study group were significantly lower than those in the control group 48 h after treatment. The dosage of noradrenaline, oxygenation index, PCT, IL-6 and blood lactate level in the study group after treatment were improved compared with those before treatment (P<0.05), while those in the control group were not significantly improved after treatment (P>0.05), and oxygenation index in the two groups had no significant difference before and after treatment (P>0.05). There was no significant difference in the 28-day survival rate between the two groups (χ2=0.211, P=0.646). Conclusion Although the hemoperfusion for absorption of inflammatory cytokine factors can not reduce the 28-day mortality of sepsis, it can significantly improve the early physical and chemical indicators of patients, and provide opportunities for follow-up treatment.