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find Author "CHEN Yunxi" 1 results
  • A Meta Analysis of Low-Dose Tacrolimus Immunosuppressive Therapy in Kidney Transplant Recipients

    【摘要】 目的 评价肾移植术后他克莫司(TAC)低剂量对比常规剂量干预的疗效和安全性。 方法 检索MEDLINE、EMbase、SCI、CBM、Cochrane图书馆,纳入肾移植术后TAC低剂量对比常规剂量免疫抑制治疗的随机对照试验(RCT)。检索时间从各个数据库建库至2009年12月,对纳入研究进行方法学质量评价和Meta分析。 结果 纳入3个RCT,其中A级研究2个,B级研究1个。分析结果显示:两组急性排斥反应发生率比较,无统计学意义[RR=1.39, 95%CI(0.64, 3.01)];肾小球滤过率、受者/移植物生存率和纳入分析的安全性指标差异均无统计学意义。 结论 基于当前临床证据,肾移植术后TAC低剂量与常规剂量干预相比,近期疗效和安全性相似;远期结果尚需进一步研究探讨。【Abstract】 Objective To evaluate the effect and safety of low-dose versus standard-dose tacrolimus immunosuppressive therapy on kidney transplant recipients. Methods MEDLINE, EMbase, SCI, CBM and the Cochrane library were searched and randomized controlled trials (RCT) of low-dose versus standard-dose tacrolimus immunosuppressive therapy in kidney transplant recipients were gathered. The search was updated in December 2009. Quality assessment and meta-analysis were performed. Results A total of three RCT were identified, two of which were graded A and one was graded B. The analysis results indicated that RR (95%CI) value of the acute rejection rate was 1.39 (0.64, 3.01); glomerular filtration rate, patient/graft survival rate, and safety analysis were not significant different between the two groups. Conclusion Based on the evidence currently, compared to standard-dose TAC, Low-dose TAC has the same effect and safety results, but further study are needed to get the long term results.

    Release date:2016-09-08 09:51 Export PDF Favorites Scan
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