ObjectiveTo discuss the treatment of retroperitoneal tumors infiltrating celiac trunk. MethodFifteen cases of retroperitoneal tumors who underwent surgery in our hospital between December 2014 to December 2015 were reviewed and analyzed. ResultsAll of the 15 cases had underwent operation, and the blood loss was 300-2200 mL (mean of 600 mL), operation time was 125-600 minutes (mean of 240 minutes). Length of stay in cases of celiac trunk resected was 10-23 days (mean of 15.1 days), and length of stay in cases of celiac trunk nonresected was 15-132 days (mean of 35.2 days). Thirty cases of them were complete resection, and 2 cases were mostly resection. Eight cases of them did not injure celiac trunk, 1 case suffered from complication, 7 cases injured celiac trunk and all of them suffered from complication. There were significant statistical difference in incidence of complications (χ2=8.14, P=0.01) in cases of celiac trunk injury or not. All the cases were followed up for 3-13 months (mean of 6.3 months), 2 cases recurred during the follow-up period, 1 case was leiomyosarcoma, and another 1 was malignant fibrous histiocytoma who underwent celiac trunk resection. ConclusionsWhen retroperitoneal tumors infiltrates celiac trunk, we can resect the celiac trunk, but we must follow a certain principle.