ObjectiveTo explore the clinical and pathological characteristics of lung carcinoma in young adults, and improve the early diagnosis and treatment. MethodsWe retrospectively analyzed 129 patients with lung carcinoma aged from 18 to 35 years old who came to West China Hospital of Siduan University from January 1st 2008 to December 31st 2014.Also we collected 32 young adults with lung benign mass to make the comparison of the clinical and pathological characteristics with the patients. ResultsIn the 129 patients with lung carcinoma, there were 72 females and 57 males.Adenocarcinoma (88/129) was the most common type of pathology, while others included small cell carcinoma (18/129), squamous cell carcinoma (13/129), and other types of carcinoma (10/129).Among patients with lung carcinoma, 41(31.8%) complained of refractory dry cough and another 40(31.0%) presented coughing and expectoration.Twenty-nine patients (22.5%) were misdiagnosed in their first visits.In young adults with lung carcinoma, 55.8% were at the Ⅳ stage with metastasis at the first-time diagnosis.Comparing with patients with benign lung mass, patients with lung carcinoma presented significantly more dry cough (P=0.011), chest distress (P=0.007) and weight loss (P=0.007);while fever was found more patients with lung benign mass (P=0.040).The differences in cough, expectoration, and emptysis between the two groups were not significant (P > 0.05). ConclusionsLung carcinoma in young adults often has atypical clinical presentations.Therefore, it is more commonly misdiagnosed.
Objective To analyze the clinical and pathological features of lung cancer with metastasis, explore the regularity and characteristics of the location of metastasis, and provide reference for future clinical treatment. Methods A total of 658 patients with lung cancer treated in West China Hospital of Sichuan University from January 2008 to December 2014 were enrolled in this study. The effect of different clinical and pathological characteristics on different locations of metastasis was analyzed by χ2 test and logistic regression. Results Adenocarcinoma was the main pathological type (342 cases, 52.0%), and bone (150 cases, 22.8%) and pleura (118 cases, 18.0%) were the most common distant metastasis. Compared with patients with no corresponding metastasis, patients with age <60 years took bigger proportions in patients with bone, brain and mediastina metastasis ( P<0.05). Furthermore, logistic regression analysis showed that the younger patients were more likely to have brain metastasis (P=0.024). Besides, the elder patients were more common in those with liver metastasis (P<0.001). The proportion of males was higher in the patients with lymph node metastasis than those without lymph node metastasis (P=0.010); however, the proportion of females was higher in patients with bone or pleural metastasis than those without bone or pleural metastasis (P<0.05). There was no significant difference in gender among patients with brain, lung, liver, adrenal and mediastinal metastases (P>0.05). Conclusions Bone and pleura are the most common sites of metastasis of lung cancer. The age structure of brain metastasis tends to be younger.