ObjectiveTo observe the effect of compound chlorhexidine gargle wash care for patients after radical surgery of tongue cancer. MethodsBetween January 2013 and March 2014, 40 patients with tongue cancer who underwent radical surgery without radiation therapy or chemotherapy before operation were selected and randomly divided into compound chlorhexidine giuconatie gargle solution group (intervention group, n=19) and traditional oral care group (control group, n=21). Then we compared the two groups in terms of bacterial colony number, oral cavity cleanness, incidence rate of bad breath and oral ulcer. ResultsBefore intervention, there was no significant diTherences between the two groups in the number of bacterial colony, oral cavity cleanness or oral odor (P>0.05). After treatment, the bacterial colony number and incidence of oral ulcer in the intervenient group were significantly lower, and oral odor was slighter than that of the control group (P<0.05). Oral cavity cleanness between the two groups was not significantly different (P>0.05). ConclusionCompound chlorhexidine gargle wash care for patients after radical surgery of tongue cancer was better than the traditional treatment in terms of bacterial colony number, incidence rate of bad breath and oral ulcer. It is worth clinical popularizing.