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find Keyword "Confidence interval" 4 results
  • Meaning and purpose of statistical measures

    In this paper, we introduce meaning and purpose of confidence interval (CI) in evidence-based medicine, For example, RRR ,ARR ,NNT. It s referance for user and doer of EBM in China.

    Release date:2016-08-25 03:16 Export PDF Favorites Scan
  • Some Statistical Issues of Confirming Efficacy in Clinical Trials

    To show that a new drug is better than, as good as, or no worse than that of a known effective drug. Theoretically, it is necessary to confirm the efficacy of a treatment, but the current practice of clinical trial suggests that there exists many problems in its confirmation including the objectives of clinical investigation vary based on the fact that more and more clinical trials use active controls. Applied statistical methods have to adapt to these changes. In this paper, we illustrated some statistical issues of confirming efficacy in clinical trials, including its conditions, the determination of clinical margin, the forms of the null and alternative hypothesis and confidence intervals, the choice of endpoints and some miscellaneous considerations. We bly suggests that it is necessary to make biostatisticians and clinical trialists understand the importance of using the right statistical methods when investigating clinical trials. We also think these methods introduced in the paper may provide some help in trial design and evaluation.

    Release date:2016-09-07 02:25 Export PDF Favorites Scan
  • Application of RevMan 5.3 software for data transformation in etiological and prognostic meta-analysis

    Etiological and prognostic studies always directly reported effect size with its 95% confidence interval, hence, data transformation was needed when performing meta-analysis based on these studies. Using the data of risk ratio, hazard ratio, odds ratio and 95% confidence interval as an example, this paper introduces the process of using RevMan 5.3 software to convert data and perform meta-analysis.

    Release date:2017-07-19 10:10 Export PDF Favorites Scan
  • Application of Stata software to conduct a meta-analysis with the effect value and its 95% confidence interval

    Most statistical data in observational studies is expressed as the effect value and its 95% confidence interval (95% CI), which do not correspond to the data format used for traditional meta-analyses, so special data conversion is to be needed when Review Manager software is applied to do a meta-analysis for this type of data, which will make the operation complicated and cumbersome. In addition, Stata software is such a powerful statistical software that can be used directly to conduct a meta-analysis with the effect value and its 95% CI. Therefore, it is an indispensable statistical tool for meta-analysis in observational studies. And this study will give a brief introduction how to use Stata software to conduct a meta-analysis with effect value and its 95% CI based on the published meta-analysis data.

    Release date:2018-03-20 03:48 Export PDF Favorites Scan
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