ObjectiveTo explore the value of ultrasound-guided core needle biopsy (CNB) in diagnosis of thyroid nodules. MethodsThe clinical data of 347 patients with thyroid nodules who underwent ultrasoundguided CNB were retrospectively analyzed, and the results of CNB pathology were compared with postoperative wax pathology results. ResultsAll patients completed CNB successfully and satisfaction rate for tissue samples was 100%. After CNB, local hematoma occurred in two cases and relieved by conservative therapy. The CNB pathology results of 347 cases of patients were as follows: 117 cases were malignancy, including papillary thyroid cancer in 115 cases, undifferentiated adenocarcinoma in 1 case, and squamous cell carcinoma in 1 case; 230 cases were benign, including thyroiditis in 53 cases, and nodular goiter in 141 cases, adenoma in 16 cases, and nodular goitre coexisting thyroiditis in 20 cases. In 132 cases of patients underwent surgery including 113 cases of malignancy and 19 cases of benign disease, the CNB pathology results in 127 cases were consistent with postoperative wax pathology results and false negative occurred in 5 cases. The diameter of thyroid nodules were not more than 0.5 cm in 4 cases, 0.5-1.0 cm in 59 cases, 1-2 cm in 46 cases, and more than 2 cm in 23 cases, and the accuracy rate of CNB pathology results was 75.0%（3/4）, 98.3%（58/59）, 97.8%（45/46）, and 91.3%（21/23）, respectively, which was the highest in 0.5-2.0 cm. The accuracy, sensibility, specificity, positive predictive value, negative predictive value, failure rate, and misdiagnosis rate of ultrasound-guided CNB for differential diagnosis of thyroid malignant nodules from benign nodules were 96.21% (127/132), 95.76% (113/118), 100% (14/14), 1 (113/113), 0.74 (14/19), 4.24%(5/118), and 0 (0/14), respectively. ConclusionUltrasound-guided CNB has important value on differential diagnosis of thyroid nodules, and important guiding significance on treatment of thyroid diseases.
ObjectiveTo explore the consistency between core needle biopsy (CNB) by color ultrasound location and surgical biopsy in the diagnosis of breast diseases. MethodsBetween March 2012 and March 2015, the results of ultrasound-guided CNB pathological examination of 218 cases of breast diseases were retrospectively analyzed, which were compared with the results of postoperative histopathological diagnosis to evaluate the ultrasound-guided CNB diagnosis. ResultsIn the 218 cases, 156 of mammary cancer were confirmed by CNB histopathological diagnosis, and 160 were confirmed by the postoperative pathological histological diagnosis; the false negative diagnosis by CNB pathological diagnosis was 4. The two methods were highly matched with each other (k=0.958,P<0.001). The sensitivity of CNB histopathological diagnosis for mammary cancer was 97.5%, while the specificity was 100.0% and the accuracy rate was 98.2%. ConclusionCNB histopathologic diagnosis of breast lesions had high accuracy and high consistency with postoperative histopathological diagnosis results, which is a reliable biopsy method for breast lesions.