Objective To systematically review the association between ALDH2 polymorphism and ischemic stroke. Methods Web of Science, PubMed, CNKI, CBM and WanFang data were searched to collect case-control studies about the association between ALDH2 polymorphism and ischemic stroke from the inception to October 2016. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then meta-analysis was performed by using Stata 12.0 software. Results A total of seven case-control studies were included. The results of meta-analysis showed that the A allele and AA genotype in ALDH2 was associated with the risk of ischemic stroke (Avs. G: OR=1.430, 95%CI 1.006 to 2.033,P=0.046; AAvs. AG+GG: OR=1.734, 95%CI 1.267 to 2.373,P=0.001; AAvs. GG: OR=1.757, 95%CI 1.274 to 2.424,P=0.001). Conclusion ALDH2 gene polymorphism may related to ischemic stroke for Chinese and A allele of ALDH2 may be the risk factors.
Objective To systematically review the association between SG13S89 polymorphism inALOX5AP gene and ischemic stroke in Chinese population. Methods Web of Science, PubMed, CNKI, CBM, EMbase and WanFang Data databases were searched to collect studies about the association between SG13S89 polymorphism inALOX5AP gene and ischemic stroke from inception to October 2016. Two researchers independently screened literature, extracted data and evaluated the risk of bias of included studies. The meta-analysis was performed by STATA 12.0. Results A total of 11 case-control studies were included. The results of meta-analysis showed that SG13S89 polymorphism inALOX5AP gene was associated with the risk of ischemic stroke in Chinese (Avs. G: OR=1.192, 95%CI 1.029 to 1.381,P=0.019; AA+AGvs. GG: OR=1.20, 95%CI 1.029 to 1.400,P=0.020; AGvs. GG: OR=1.195, 95%CI 1.022 to 1.397,P=0.025). Conclusion SG13S89 polymorphism inALOX5AP gene may be related to ischemic stroke for Chinese, A allele may be a risk factor.
Objectives To investigate the relationship between SG13S114 and SG13S32 polymorphisms in ALOX5AP gene and risk of ischemic stroke in Chinese population. Methods We searched Web of Science, EMbase, PubMed, CNKI, CBM and WanFang Data databases to collect case-control studies on SG13S114 and SG13S32 polymorphisms of ALOX5AP gene and risk of ischemic stroke in Chinese from inception to February 2017. Two reviewers independently screened literature, extracted data, and assessed the risk of bias of included studies. Meta-analysis was then performed by Stata 12.0 software. Results A total of 20 studies were included. The results of meta-analysis showed that SG13S114 polymorphism in ALOX5AP gene was associated with risk of ischemic stroke in Chinese (A vs. T: OR=1.12, 95%CI 1.00 to 1.27, P=0.05; TA+AA vs. TT: OR=1.14, 95%CI 1.01 to 1.28, P=0.04; AA vs. TT: OR=1.33, 95%CI 1.07 to 1.65, P=0.012). However, no significant association between SG13S32 polymorphism and ischemic stroke in Chinese was found. Conclusions SG13S114 polymorphisms in ALOX5AP gene is associated with risk of ischemic stroke in Chinese, in which the A allele of ALOX5AP may be a risk factor.