【Abstract】ObjectiveTo investigate the expressions of aromatase (Arom) and survivin (Surv) in primary hepatocarcinoma(PHC), and explore their relationships with the clinicopathology of PHC. MethodsThe specimens from 47 patients with PHC were fixed in 10% formalin and routinely embedded in paraffin. The specimens were continuously sliced into 4 μmthick sections. ABC immunohistochemistry was performed to detect the expressions of Arom and Surv with polyclonal antibodies and scored them under highpower microscopy. Results The positive rates and the scores of Arom and Surv in cancer tissues were significantly higher than those of the paratumor tissues 〔Arom: 40.43% vs 21.28% (P＜0.05), 1.53±1.69 vs 0.79±1.41 (P＜0.05); Surv: 63.83% vs 31.91% (P＜0.01), 2.40±1.96 vs 1.45±1.80 (P＜0.05)〕. The score of Surv in tumors with the maximal diameter ＜5 cm (4.00±2.10) was significantly higher than that in tumors with the maximal diameter ≥5 cm (2.17±1.86)， P＜0.05. However, there was no relationship between the expressions of Arom and Surv in PHCs and other clinicopathologic features of the PHCs. The positive correlation was found between the score of Arom and that of Surv in PHCs （r=0.316，P＜0.05）. ConclusionThe expressions of Arom and Surv might be closely related to the carcinogenesis and development of PHC.