【摘要】 目的 通过对早期妊娠卵黄囊的观察，探讨其在早孕超声诊断中的临床价值。 方法 2008年5月-2009年1月应用阴道超声诊断仪观察536例早孕患者卵黄囊的形态、大小及卵黄囊的数目，根据结果分为卵黄囊正常及异常组，比较卵黄囊的增长情况与妊娠预后的关系。 结果 504例正常组中，501例正常妊娠结局的卵黄囊大小从孕5~11周持续增长，此后逐渐缩小，孕12周后消失；另3例为宫外孕而中止妊娠。卵黄囊异常组32例。正常组和异常组的卵黄囊大小及形态有统计学意义（Plt;0.05）。 结论 卵黄囊超声影像学改变可作为诊断早孕及预测妊娠发展和转归的可靠手段。【Abstract】 Objective To evaluate the clinical value of yolk sac in the diagnosis of early pregnancy by observing the change of yolk sac. Methods The yolk sacs in 536 pregnant women were measured by ultrasonogaphy from May 2008 to January 2009, and the correlation of the growth condition of the normal or abnormal yolk sac with pregnancy outcome were observed. Results In the normal group (504 patients), the yolk sac size of 501 patients continued to grow from five to 11 weeks of pregnancy, then gradually reduced and disappeared after 12 weeks of pregnancy. The other three patients terminated pregnancy because of ectopic pregnancy. Thirty-two cases of abnormal yolk sac were found. The results showed the size and shape of yolk sacs were significantly different between normal and abnormal groups (Plt;0.05). Conclusion The change of yolk sacs by ultrasonography during early pregnancy can be used as a good measure to diagnosis early pregnancy and predict the development and prognosis of pregnancy.