ObjectiveTo analyze the relation between age and postoperative pathological features of patients with colorectal cancer from Database from Colorectal Cancerr （DACCA）. MethodsThe data in DACCA were updated on January 5, 2022. The patients were selected from DACCA according to the established screening conditions, then were divided into ≤35, 35–59, and ≥60 years old groups. The differences of postoperative pathological （p） TNM （pTNM）, pT, pN, pM stages, perineural invasion （PNI）, high-risk factors grade, and tumor regression grade （TRG） among the three age groups were analyzed, and the correlation between them was analyzed. ResultsAfter screening, 5 628 data rows were enrolled, of whom 196 patients were <35 years old, 2 382 patients were 35–59 years old, and 3 050 patients were >59 years old. Statistical analysis showed that: ① There were statistical differences in the proportions of pN stage, PNI, and high-risk factors grade in the patients of different age groups （H=27.867, P<0.001; H=6.248, P=0.044; H=19.712, P<0.001, respectively）; However, it was not found that there were statistical differences in the proportions of pTNM, pT, pM stages, and TRG after neoadjuvant therapy among different age patients （H=0.920, P=0.631; H=4.923, P=0.085; H=2.272, P=0.321; H=2.337, P=0.311, respectively）. The Spearman correlation analysis results showed that there was a weakly negative correlation between the age and pN stage or grade of high-risk factors （rs=–0.070, P<0.001; rs=–0.067, P<0.001, respectively） and a weakly positive correlation between age and TRG after neoadjuvant therapy （rs=0.100, P=0.009）. ConclusionDACCA data analysis finds that patients of different age groups shows a negative correlation trend with pN stage or grade of high-risk factors and a positive correlation trend with TRG, which needs to be further verified.
ObjectiveTo analyze the relation between ABO blood type and postoperative pathological features of patients with colorectal cancer served by West China Hospital of Sichuan University as a regional center in the current version of Database from Colorectal Cancer (DACCA). MethodsThe data of DACCA was updated on January 5, 2022. According to the screening conditions, the enrolled patients with colorectal cancer were divided into blood type A, B, AB, and O. The differences in the postoperative pathological characteristics of patients with different blood types, such as pathological TNM, T, N, M (pTNM, pT, pN, pM) staging, peripheral nerve involvement, high risk factors, tumor regression grade (TRG), and cancer nodules, were analyzed. ResultsAfter screening, 6 089 data rows were analyzed. The patients involved 2 058 blood type A, 1 469 blood type B, 494 blood type AB, and 2 068 blood type O. The results of statistical analysis showed that: ① There were statistical differences in the overall distribution of pTNM and pM stages among the patients with different blood types (H=11.564, P=0.009; H=7.947, P=0.047), which was reflected in: from the overall distribution trend, the proportion of patients with the four blood types in the same stage was similar, but it could still be seen that patients with blood type AB accounted for the highest proportion in the patients with stage Ⅲ, Ⅳ, M1a, M1b as compared with other blood types. ② There were no statistical differences in the overall distribution of peripheral nerve involvement and TRG in the patients with different blood types (H=3.414, P=0.332; H=1.143, P=0.767). ③ There was statistical difference in the proportion of different grades of high risk factors in the patients with different blood types (H=14.540, P=0.002). Specifically, the proportions of patients with grade 3–5 of high risk factors in the patients with AB blood type were the highest. ④ There was no statistical difference in the proportion of the grade of cancer nodules number in patients with different blood types (H=4.460, P=0.216). ConclusionsFrom results of this study, it is found that there are some differences in pTNM stage, pM stage, and high risk factors of colorectal cancer patients with different blood types, but no differences in pT stage, pN stage, peripheral nerve involvement, TRG, and cancer nodules among different blood types of patients. The influence of blood type on postoperative pathological characteristics of colorectal cancer patients needs to be further explored.
Objection To analyze the relationship between blood type and prognosis of colorectal cancer patients in the Database from Colorectal Cancer (DACCA). Methods The DACCA version selected for this data analysis was updated on January 5, 2022. The data items analysis included age, gender, blood type, tumor location, tumor pathological nature, pathological TNM (pTNM) stage, survival status and survival time. According to the ABO blood type classification, it was divided into four blood type groups: A blood type group, B blood type group, AB blood type group, and O blood type group. The overall survival (OS) and disease specific survival (DSS) were analyzed in four blood type groups, and the OS and DSS of each blood type group were analyzed in pTNM stage stratification. Results A total of3 486 rows of data were obtained from the DACCA database according to the screening conditions. There was no significantdifference in OS and DSS among blood typy A, B, AB and O group (P>0.05); At specific time points, the 1-year OS of the blood type A group was worse than that of blood type B (95.8% vs. 99.6%), the 1-year OS of the blood type B group was better than that of blood type O group (99.6% vs. 96.9%), and the differences were statistically significant (P<0.008 7), but the differences between OS and DSS in the remaining 1, 3, 5 and 10 years of patients with different blood type groups were not statistically significant (P>0.008 7). In each pTNM staging subgroup, the differences between 1, 3, 5 and 10-year OS and DSS were not statistically significant among different blood type groups (P>0.008 7). Conclusions Overall, there was no significant difference in prognosis among the blood type A, B, AB, and O groups. Comparing specific blood types and follow-up time, patients with blood type B have slightly better 1-year OS than patients with blood type A or blood type O. Comparisons between other ABO blood groups and between ABO blood groups classified by the pTNM staging subgroup did not show a difference.
ObjectiveTo analyze the relationship between educational level and oncological characteristics of colorectal patients served by Sichuan University West China Hospital in the current version of the Database from Colorectal Cancer (DACCA). MethodsThe DACCA version selected for this data analysis was the updated version on June 29, 2022. The data items analyzed included: educational level, precancerous lesions, family history of cancer, tumor location, tumor orientation, tumor pathology, tumor morphology, tumor differentiation and preoperative TNM staging. According to Article 17 of the Education Law of the People’s Republic of China, the educational level of the research subjects was divided into four categories: illiteracy group, the primary educated group (elementary school), the secondary educated group (middle school, high school, vocational school and technical school), and the higher educated group (university, higher vocational school, junior college and above). ResultsThe DACCA database was filtered by conditions to obtain 5 512 valid data. The data analysis results showed that there were statistically significant differences in the composition ratios of precancerous lesions (χ2=27.398, P<0.001), tumor site (χ2=42.610, P<0.001) and tumor orientation (χ2=18.967, P=0.025) among the different education groups, and there were not statistically significant differences in the composition ratios of family history of cancer in oneself (χ2=9.345, P=0.133) or in the family (χ2=4.310, P=0.635), tumor pathological properties (χ2=27.027, P=0.202), tumor morphology (χ2=16.283, P=0.061), tumor differentiation degree (H=3.672, P=0.299) and the TNM staging of tumors before operation (H=0.156, P=0.984) among the different education groups. ConclusionsData analysis in DACCA reveal multiple associations between educational level and oncological characteristics of colorectal cancer patients. The education level of patients has a certain reference value in the investigation of various precancerous lesions. With the increase of education level, the proportion of tumors located in the rectum gradually decreases, and the proportion located in the colon gradually increases, and education level may affect treatment and prognosis by influencing preoperative tumor characteristics.
Objective To analyze the impact of age on surgical reaction and postoperative complications of patients with colorectal cancer served by West China Hospital of Sichuan University as a regional center in the Database from Colorectal Cancer (DACCA). Methods The data of DACCA was updated on January 5, 2022. All data items included age, surgical trauma reaction, elevated body temperature time, exhaust time, pain, mental status, and postoperative hospital complications. According to the age segmentation method in China, the patients can be divided into 3 groups: ≤35 years old (including infant, toddler, child, teenager and youth, set as the younger group), 36–59 years old (set as the middle-aged group), and ≥60 years old (set as the elderly group). Results After scanning, 5 224 data rows were analyzed. There was no significant difference in surgical trauma reaction (H=0.352, P=0.838), elevated body temperature time (H=3.999, P=0.135), exhaust time (H=1.940, P=0.379), mental status (H=2.075, P=0.354), incidence of postoperative complications (χ2=2.078, P=0.354), incidence of anastomotic bleeding (χ2=1.737, P=0.420), incidence of anastomotic leakage (χ2=0.573, P=0.751), and incidence of pulmonary infection (P=0.410) among different age groups, but the younger group had more severe pain (H=12.985, P=0.002) and higher incidence of inflammatory obstruction (χ2=7.789, P=0.020). Conclusions Age has little effect on trauma reaction related parameters and overall incidence of complications in colorectal cancer patients. However, younger patients with colorectal cancer showed increased pain levels and increased incidence of inflammatory obstruction after surgery. These clinical manifestations can provide clinicians with evidence for intervention, but more prospective intervention trials are needed.