ObjectiveTo investigate the effects of single-disease quota payment in Chengdu.MethodsThe data of medical insurance in Chengdu from 2009 to 2013 were used to compare changes of average hospitalization expenses, hospitalization days, re-admission rate and so on by establishing a difference-in-difference (DID) model.ResultsThe quota payment policy effectively controlled the overall medical expenses. Drug fee and examination fee were significantly affected (P<0.01). However, the re-admission rate was significantly improved (P<0.10).ConclusionThe implementation of single-disease quota payment in Chengdu controlled the medical expanses growth effectively, but it is necessary to prevent its side effects.