Objective To discuss the way and management of cardiopulmonary bypass （CPB） through intubation of femoral artery and femoral vein for completely video assisted cardiac operations, Methods CPB were set up through femoral artery and femoral vein in 85 patients on heart surgery by video assisted thoracotomy. Thirtyeight patients were diagnosed as atrial septal defect （ASD）, forty-three patients were diagnosed as ventricular septal defect （VSD）, and four patients were mitral valve stenosis and mitral incompetence （MS＋MI）,The video assisted thoracotomy was used to repair ASD, VSD and mitral valve replacement （MVR）. Results For all patients the durations of CPB and aortic cross-clamping time was 30-179 min（91.7±27.4 min）, 6-103 min（37.2±6. 1 min）. In one patient, the CPB was set up again for repairing of residual leak. The endothelium of femoral artery was lacerated during withdrawing the cannula in 2 patients. Conclusion The video assisted thoracic operation with CPB and by intubation of femoral artery and femoral vein to perform heart operation are feasible and safe. All patients are recovered well.