An experimental study on Holland pigs was designed to evaluate the effect of direct current stimulation on the rate of epidermie regeneration. The 44 animals were divided into four groups, each of eleven animals and the stimulation levels were 10~uADC, 30~uADC, 50~uADC,0~uADC respectively. The results showed that the rate of regeneration of epidermic cell and wound healing was faster with the DC stimulation directly than indirectly, especially in the area of negative electrode and the rate of wound healing with the DC stimulation indirectly was faster than without DC stimulation. Proper applications dircct eurrent of appropriate intensity were definitely beneficial in the treatnent of patienls donor site after removing a thick split-thickness skin graft.