Mitochondrial DNA (mtDNA) is the circulating genome in mitochondria, and it is easy to accumulate oxidative damage, causing mitochondrial dysfunction, and then cell dysfunction, and even tissue and body pathological changes, leading to diseases. As a pro-inflammatory, inflammatory, and even predictive factor, mtDNA is directly involved in the inflammatory response and the pathogenesis of many diseases. This article aims to review the current pathogenesis of mtDNA damage and its pathogenic role in various human diseases.
The patient is a 71-year-old male with esophageal cancer and aortic vavle regurgitation. At present, the treatment strategy of such patients is controversial. For the elderly patients with esophageal cancer who do not need neoadjuvant treatment, considering the risk of cardiopulmonary bypass and the potential risk of esophageal cancer metastasis, we have successfully implemented apical catheter aortic valve implantation and minimally invasive three-incision thoracolaparoscopy combined with radical resection of esophageal cancer (McKeown) at the same period.