【Abstract】Objective To discuss the application of endoscopic diagnosis and treatment of biliary stone with choledochofiberscope after orthotopic liver transplantation.Methods Five patients with repeated infection of bile duct and obstructive jaundice were treated with choledochofiberscope through T tube sinus, combining with the plasma shock wave lithotripsy, the eyewinker clam and the basket extraction. Results We could efficiently extract the biliary tract stone through choledochofiberscope combining with plasma shock wave lithotripsy, eyewinker clam and basket extraction; and observe the healing appearance, and blood circulation of the biliary tract. Conclusion The choledochofiberscope can be used to diagnose and treat biliary tract stone of orthotopic liver transplantation. The choledochofiberscope and T tube will be important in diagnosis and treatment of biliary tract stone following orthotopic liver transplantation.