OBJECTIVE: To further explore the effects of fibroblast growth factor on soft tissue repair. METHODS: Based on the data from our experiments and clinical trial and data from other reports, a further reconsideration about fibroblast growth factor and soft tissue repair was demonstrated, including embryonic development, histology, animal experiments, clinical trial and prospect. RESULTS: Amounts of basic and clinical data showed that fibroblast growth factor was needed in embryonic development. Exogenous fibroblast growth factor could accelerate wound healing. CONCLUSION: Fibroblast growth factor is a bioactive protein which can obviously promote wound healing, it has broad prospects of clinical application.
Objective To review the advance in the experimental studies and evaluate the potential therapeutic application of the mesenchymal stem cells(MSCs). Methods The related articles published in China and theother countries during the recent years were extensively reviewed and analyzed. Results The MSCs were widely used in the cell-transplantation therapy and the tissue engineering because of their pluripotency of differentiation into various kinds of cells. They were also frequently used in the gene therapy because they could stably express the transfected objective genes. Because of their immunomodulatory function, the MSCs could also be used in the immunotherapy. Conclusion The MSCs are the stem cells, which have characteristics of renewing themselves, having multipotency, and being easy to undergo amplification in vitro.The MSCs are ideal target cells for the cell therapy, tissue engineering, gene therapy, and immunotherapy.
Objective To investigate the expression of ectodysplasin (EDA) genesignaling and its relationship with the development and regeneration of sweat glands. Methods The articles concerned in the latest years wereextensively reviewed. Results EDA gene is an important signaling pathway associated with the developmental procedure of sweat glands in early fetal stage. Abnormality or depletion of function in sweat glands partially owed to the defect of EDA gene. Conclusion EDA signaling has its biological significance in inducing development and morphogenesis of sweat glands and in maintaining physiological function of skin. It could be a new approach to repair or regenerate the sweat glands for clinical therapy by regulating the expression of EDA gene.