Objective To study anatomy of mortis corona vascular and analyze its characteristics and clinical significances in laparoscopic total extraperitoneal hernia repair (TEP). Method The clinical data of 45 patients with inguinal hernia underwent laparoscopic TEP from July 2013 to October 2015 in the Fourth People’s Hospital of Zigong City were collected. Results ① There were 45 patients with inguinal hernia a total of 52 bilateral inguinal hernias (15 direct hernias, 37 oblique hernias). The total appear rate of corona mortis vascular was 61.5% (32/52). The appear rate of corona mortis artery was significantly higher than that of the corona mortis vein〔46.2% (24/52)versus 34.6% (18/52),P<0.05〕, the diameter of the corona mortis artery was significantly smaller than that of the corona mortis vein〔(3.2±0.3) mmversus (3.4±0.4) mm,t=2.231,P<0.05〕. ② The appear rates of corona mortis artery and vein in the male patients were significantly higher than those of the female patients (P<0.05). Compared with the female patients, the age of onset was older (P<0.05), thickness of abdominal wall was thinner (P<0.05), diameter of corona mortis vascular was bigger (P<0.05) in the male patients. ③ The total appear rate of corona mortis vascular in the patients with direct hernia was significantly lower than that of the patients with oblique hernia (P<0.05). The age of onset of the patients with direct hernia was significantly older than that of the patients with oblique hernia (P<0.05). Conclusions There is a higher appear rate of corona mortis vascular in patients with oblique hernia, which in male patients is higher as compared with female patients. Age of onset of male patient with inguinal hernia is older than that of female patient with inguinal hernia. It suggests that appear of corona mortis vascular might be associated with degeneration of abdominal wall. It has a certain role for localization and avoidance of corona mortis vascular in TEP.