ObjectiveTo explore the effect of quality control circle (QCC) on the management of hospital medication. MethodsAccording to the existing problems between December 2013 and January 2014, we put forward a series of continuous improvement plans, strengthened the nurses training, and intensified the supervision methods from February to May 2014. ResultsAfter the implementation of QCC, the incidence of leakage from drugs significantly decreased from 15.8% to 0.0%; the nurse-related drug management knowledge rate increased from 64.1% to 92.3%. Withdrawal process execution rate increased from 71.8% to 100.0%, and the difference was statistically significant (P<0.05) from February to May 2014. ConclusionQCC activity improves the hospital medication management, increases the nurses' sense of responsibility, and ensures the medical security of hospitalized patients.