Purpose To observe the clinical features and visual acuity of the eyes with idiopathic macular holes. Methods We reviewed the clinical materials of 23eyes of 18 patients with idiopathic macular holes and the follow up results from 6 to 120 months. Results In the initial examinations of 22 eyes,the numbers of eyes with stagesⅠ-Ⅳ macular holes were5,4,10,3 eyes respectively,and funds fluorescein angiography showed there were focal transmission of choroidal fluorescein in 17 eyes (stagesⅡ～Ⅳ).Macular hole ocurred in one eyes during follow up.At the final examination of 23 eyes,the numbers of eyes with stages Ⅰ～Ⅳ macular holes were 2,2,9,8 eyes respectively .Full-thickness macular hole of 2 eyes closed naturally after posterior vitreous detachment.The time interval of the subjective visual loss on stage Ⅰ was 5-8 months,stageⅡ8-20 months,stageⅢ12-126 months ,and the average visual acuity on stageⅠwas 0.7,stage 0.55,stageⅢ0.08,and stage Ⅳ0.08 Conclusion Approximately 60% of impending (stage Ⅰ) hole progress to full thickness holes, the full thickness holes were usually enlarged and the visual acuity of affected eyes decreased as the natural course was prolonged . (Chin J Ocul Fundus Dis,1998,14:222-223)
OBJECTlVE:To investigate Ihe changes of macuiar lesions in dry type of age re[amd maeuJar clegcneration(AMD)and search for a sensitive melhod for detecting tile development of the disease. METHODS:The fundus fluoreseein angiography(FFA) ,visual acuity,FM 100-hue test and photopie electroretinogram(ERG)were used to examine a series of 60 patients(111 eyes)with dry AMD aged 50~80 years with the visual acuity of le;1.0.The patients were felhwed tip in 3~74 months(average 30.2 months). RESULTS:In 68 eyes undergone FFA examination and followed llp for Ihe average period of 25.6 months ,the macular lesions were found worsened in 25%, The visual acuity in follow-up periods was found decreasing more than 2 lines in 18% of the fotal 111 affectd eyes.There were not any statistically significat difference in photopic ERG between the initial and final cxaminations in 63 eyes tested. The tolal error score of FM 100-hue test had a statistically significant difference between the initial test and the test taken two years afterwards(Plt; 0.01 )in 81 eyes examlnccl. CONCLUSIONS:Most of the macular lesions and visual acuity in dry type of AMD revealed a [avorahle prognosis,but occasionally complicated with ehoroidal neovaseularization. The total error score of FM 100-hue test might be a sensitive method for monitoring the development of dry type of AMD. （Chin J Ocul Fundus Dis,1997,13: 150-152）
ObjectiveTo study the survival rate and death cause of patients with polymyositis (PM) and dermatomyositis (DM). MethodsBased on the Bohan and Peter diagnosis standard, DM (n=52) and PM (n=98) hospitalized patients between January 1, 2008 and January 1, 2013 were chosen to be followed up to January 2013, or to their death. Sex, age, disease entities, course of the disease, muscle creatine enzyme, interstitial lung disease, connective tissue diseases, lung infection, cardiac involvement, respiratory muscle paralysis, JO-1 antibody, hypoalbuminemia, tumor, and long-term hormone and immune inhibitor treatment were the influencing factors of death. ResultsThirty-eight patients died during the follow-up period, and the 1-, 3- and 5-year survival rate were 87.7%, 74.5% and 55.9% respectively. Cox regression analysis showed that interstitial pneumonia (RR=12.119, P=0.001), heart disease (RR=2.935, P=0.020) and tumor (RR=3.735, P=0.048) were the unfavorable factors of death, while long-term hormones (RR=0.329, P=0.024) and persistent immunosuppressant therapy (RR=0.148, P=0.022) were protective factors. ConclusionThe five-year survival rate of patients with PM/DM is still low, and pulmonary interstitial disease, tumor, cardiac involvement, and pulmonary infection are the major dead causes, while long-team immunosuppression and hormone therapy can decrease the PM/DM mortality.