ObjectiveTo systematically review the health-related quality of life (QOL) based on EQ-5D instrument for disease population in China. MethodsWe searched databases including PubMed, The Cochrane Library (Issue 5, 2015), EMbase, CNKI, VIP and WanFang Data from inception to August 2015, to identify studies involving healthrelated QOL about different diseases in China. A descriptive analysis was used to analyze health utility by disease and the proportion of patients who having problem in five dimensions, as well as comparing health-related QOL in different diseases. ResultsA total of 26 studies were included, involving 15 kinds of diseases. The health utility in different studies about the same disease was different. Diabetes ranged from 0.79 to 0.94, liver disease infected by HBV was from 0 to 0.80, hypertension was from 0.78 to 0.93, coronary heart disease was from 0.75 to 0.90, and chronic obstructive pulmonary disease was from 0.64 to 0.73. After ranking the health utility of fifteen kinds of diseases, the utility of kashin-beck disease and rheumatoid arthritis were 0.45 and 0.56, respectively, and the utility of children cerebral palsy was 0.44, which was the lowest. "Pain/discomfort" was the dimension with highest proportion of patients who having problem for most diseases while atrial fibrillation and children cerebral palsy were the "Self-care" and "Usual Activities". ConclusionEQ-5D is widely used in health-related QOL studies among different diseases in China. Many factors including sample source, severity of disease, complication and value set have influence on the measurement results of health utility.