We searched randomized controlled trials, meta-analysis and systematic reviews from OVID-EBM Reviews which included ACP Journal Club, The Cochrane Library, and MEDLINE（1991 to 2005 ） to evaluate clinical effectiveness of pit and fissure sealants for caries. The resultsshowed that pit and fissure sealants were recommended to prevent caries of the occlusal surface. The effectiveness varied between the two types of sealants, in general, flowable resin composite had a more satisfactory retention than glass ionomer composite. Acid etch was helpful for less microleakage and more satisfactory retention. Mechanical air-abrasion with acid etch may have the best border seal, However, we were not sure of the effectiveness of Er：YAG laser, technique of dental drill preparation and splicing. More high quality clinical trials on pit and fissure sealants are still needed.
目的:探讨颅脑损伤合并视神经损伤的发病机制及治疗.方法:对23例颅脑损伤合并视神经损伤患者的临床资料做回顾性分析。结果:经过积极治疗部分患者视力有不同程度改善。结论:治疗颅脑损伤合并视神经损伤,强调神经外科和眼科协同处理,掌握治疗时机。