ObjectiveTo explore the related risk factors of polypoid lesions of gallbladder (PLG) in civil aviation flight cadets and the health management measures for the risk factors. MethodsRetrospective analysis of the 2022 flight annual medical students, according to the B ultrasound examination results have PLG, divided into PLG group (n=128) and non-PLG group (n=150), collect the basic data of the students, and establish a multivariate logistic regression equation model to analyze the related risk factors of gallbladder polypoid lesions. ResultsThe results of univariate analysis showed that there was no significant difference between groups with hypertension, hyperlipidemia and hyperglycemia (P>0.05), but with age and body mass index, high total bilirubin in serum and hyperuricemia, regular schedule and diet, and sufficient exercise (P<0.05). The results of multivariate logistic regression equation model analysis showed that age, high serum total bilirubin, hyperuricemia, irregular sleep and rest, irregular diet and lack of exercise were independent risk factors for PLG. ConclusionsAge, high serum total bilirubin, hyperuricemia, irregular work and rest, irregular diet and lack of exercise are the main reasons for PLG in civil aviation flight cadets. Intervention and prevention of risk factors can effectively ensure their health and flight safety.