Objective To evaluate the applied value of group psychotherapy intervention in patients with malignant bone tumor. Methods From May 2015 to February 2016, 66 patients with malignant bone tumor were divided into the intervention group (n=30) and the control group (n=36) according to their preference. Patients in the intervention group were treated with psychological intervention and the ones in the control group were only received regular telephone follow-up guidance. The quality of life, mood, social support and other changes were collected and compared between the two groups. Results The patients’ overall health and quality of life scores, emotional function scores and Social Support Revalued Scale scores in the intervention group (75.2±21.4, 59.2±10.5, 39.20±5.60) were higher than those in the control group (68.3±14.7, 51.4±11.4, 35.30±5.30), while the patients’ Self-rating Anxiety Scale scores, Self-rating Depression Scale scores, self-blame, and retreat scores in the intervention group (39.2±8.3, 35.1±6.7, 0.29±0.22, 0.41±0.22) were lower than those in the control group (44.2±7.5, 40.9±7.7, 0.34±0.24, 0.50±0.41), and the differences were all statistically significant (P<0.05). Conclusion The implementation of group psychotherapy intervention in patients with malignant bone tumor can effectively ameliorate the patients’ negative emotions, and improve social support and coping styles status of the patients.