ObjectiveTo investigate the significance of professional pre-hospital rescue and the effect of hospital treatment on the physical and mental health for extensively gas explosion injured patients. MethodsEarly pre-hospital management and hospital treatment were both implemented for 28 injured patients in extensively gas explosion between January 2003 and May 2013. ResultsAll the 28 patients underwent strict early management and hospital treatment, including telephone reception, condition judgment, first aid, and hospital treatment. One patient died before being hospitalized, and others patients were cured and discharged from the hospital. ConclusionIt is effective to implement timely, standardized pre-hospital care in reducing mortality and it is important to implement comprehensive treatment for patients to recover their physical and mental health.