Objective To investigate the preventive measures for bleeding in laparoscopic hepatectomy. Methods The candidates for laparoscopic hepatectomy were 22 patients with live lesions, including 5 patients with primary liver cancer, 16 patients with liver hemangioma, and 1 patient with metastatic liver cancer. The tumors locatedthe left lateral lobe in 15 cases, caudate lobe in 1 case, segmentⅣin 2 cases, and segmentⅥ in 4 cases. The meandiameter of tumors was 4cm (2-10cm). The surgical approaches included the left lateral lobectomy (15 cases), leftlateral lobectomy of caudate (1 case), and nonanatomic and wedge resection were performed in 6 cases. Results Twenty-two cases underwent laparoscopic liver resection, there were no conversion to open and operative death. The mean operative time was 115min (65-142min), the mean blood loss was 450mL (270-780mL), the mean length of hospital stay after operation was 6.5 days (3-11 days). Conclusion Control liver section hemorrhage is a key technique in laparoscopic hepatectomy.