ObjectiveTo recognize the recent research progress in the prevention of duodenal stump leakage (DSL) after laparoscopic radical gastrectomy (LRG) for gastric cancer, so as to find a new breakthrough point for reducing the occurrence of DSL. MethodA review was conducted by searching recent domestic and international literature on the prevention and management of DSL after LRG for gastric cancer. ResultsAt present, the risk factors of DSL after LRG were generally recognized in the literature, including patients’ relevant factors and surgery relevant factors. The relevant factors of the patients themselves mainly were old age, malnutrition, and basic diseases; The factors relevant surgery mainly included surgical instruments, doctors’ operation level, etc. According to the literature, the measures taken for patients’relevant factors mainly included preoperative improvement of nutritional status and control of the basic diseases; The preventive measures adopted for the operation relevant factors mainly included carefully intraoperative operation, improving the anastomosis skills, and tacit cooperation of the team, which could reduce the occurrence of DSL. There was still controversy about the effect and method of routine duodenal stump reinforcement during operation. ConclusionsThe focus of reducing the occurrence of DSL is prevention. In clinical practice, patients with high-risk factors should receive special attention, with efforts to improve their condition, implement individualized decision-making, and perform meticulous intraoperative techniques to minimize complications, promote rapid postoperative recovery, and maximize patient benefits.