Primary liver cancer is the sixth most common malignancy and the third leading cause of cancer-related death worldwide, and hepatocellular carcinoma (HCC) constitutes the majority of primary liver cancer cases. The Liver Imaging Reporting and Data System (LI-RADS) was introduced to standardize the lexicon, acquisition, interpretation, reporting, and data collection of imaging results in patients at increased risk for HCC. LI-RADS allows effective categorization of focal liver lesions, and has been applied in the full clinical spectrum of HCC from diagnosis, biological behavior characterization, prognosis prediction, to treatment response assessment. This review aimed to summarize the recent applications of CT/MRI LI-RADS in the diagnosis, biological behavior characterization and prognosis prediction of HCC, discuss current challenges and shed light on potential future directions.
ObjectiveTo summarize the current status and progress of MR imaging in field of rectal cancer.MethodsThe recent literatures on this topic were reviewed and analyzed, then the key information they provide was integrated.ResultsBesides its measurement of tumor height and length, the MR imaging was also significant in the preoperative assessments of tumor staging and prognostic factors such as the extramural vascular invasion (EMVI), circumferential resection margin (CRM), and perineural invasion (PNI). However, some drawbacks couldn’t be neglected. For instance, the conventional MR imaging was of limited use in discriminating T1, T2 and borderline T3 rectal cancer. The similar limitation applies to situation between T3 and T4a rectal cancer as well. And its performances in the N staging prior to and post-neoadjuvant chemoradiation therapy were just average. Currently the functional MR imaging like the diffusion weighted imaging (DWI), some relatively novel modalities such as the dynamic contrast enhanced MRI and chemical shift have served in the radiological diagnosis of the rectal cancer.ConclusionsMR imaging is the most frequently used modality in preoperative assessment of rectal cancer. It can describe size and location of tumor, assist in tumor staging, and evaluate prognostic factors. And it is supposed to provide critical information on decision making and prognosis judging. Besides current value of conventional MR imaging in the field of rectal cancer, some innovative techniques have shown moderate potentials as well. Due to their promising future use, detection of new biomarkers regarding rectal cancer can be expected.
ObjectiveTo summarize the experience of the whole process management of hepatocellular carcinoma (HCC) patients with high-risk of recurrence and metastasis based on the multidisciplinary team (MDT) mode, and to improve the clinicians’ understanding of the concept of whole process management, so as to improve the survival rate of patients with HCC. MethodThe clinicopathologic data of a HCC patient with high-risk of recurrence and metastasis admitted to the Division of Liver Surgery, Department of General Surgery, West China Hospital of Sichuan University were retrospectively analyzed. ResultsA 52-year-old male patient was diagnosed with HCC with intrahepatic metastasis (China liver cancer staging Ⅱ b, Barcelona Clinic Liver Cancer stage B) after admission due to “epigastric discomfort for 1+-month and liver occupying for 1+-week”. Through discussion by the MDT mode, the allogeneic liver transplantation was performed after successful downstaging following two conversion therapies. No serious complications occurred after operation, and the patient was discharged on the 23rd day after operation. Up to now, pulmonary bacterial and fungal infections and pulmonary metastases had been found during the postoperative follow-up. After anti-infective therapy and targeted therapy combined with radiotherapy, the patient was significantly relieved, had survived for 34 months after operation, and was still under regular follow-up. ConclusionsFor HCC patients with high-risk of recurrence and metastasis, MDT mode has a good clinical benefit for the whole process management of patient. Through the MDT model, the diagnosis, treatment, and follow-up of HCC are organically integrated, and the patient’ s diagnosis and treatment plans are dynamically adjusted to realize the whole process management of HCC patient, and to raise the survival rate and improve quality of life of HCC patient.