目的 总结胸部创伤流行病学及临床特征，为创伤的预防和救治提供科学依据。 方法 回顾性分析 2005～2015 年我院胸心外科连续收治 1 250 例胸部创伤患者的临床资料。根据患者伤情，分别采用无创性保守治疗、胸腔闭式引流术、开胸探查止血术、肋骨内固定术及其他胸部及心脏创伤的修补术。观察创伤患者致伤类型、创伤部位、治疗方式与临床预后以及 2012 年前后时间分布及其相关性。 结果 全组男 999 例（79.9%）、女 251 例（20.1%），平均年龄（44.0±17.7）岁。非穿透性损伤 885 例（70.8%），穿透性损伤 365 例（29.2%），死亡 8 例（0.64%）。肋骨骨折 766 例，骨折内固定手术干预占 16.1%（123/766），手术复位内固定患者平均住院时间明显短于保守治疗患者（9.55 dvs. 16.38 d，t=6.574，P=0.000）。2012 年后非穿透性损伤较 2012 年前有所升高（81.8%vs. 66.3%），而穿透性损伤较前明显下降（18.2%vs. 33.7%）（χ2=28.9，P=0.000）。2012 年前后创伤部位中肋骨骨折（P=0.000）、肺挫伤（P=0.000）、气胸（P=0.000）和胸腹联合伤（P=0.001）均发生了明显变化。 结论 2012 年是我院 10 年期间胸部创伤类型及创伤部位发生明显变化趋势的重要时间截点，对我院下一步胸部创伤救治侧重点转变带来了新的思考和考验。
ObjectiveTo explore the effect of body mass index (BMI) on the outcomes of laparoscopic surgery for esophageal hiatal hernia.MethodsWe divided the patients who underwent hiatal hernioraphy and fundoplication surgery in our hospital between July 2013 and June 2018 into two groups according to the BMI: a group A, BMI ≥24 kg/m2, 77 patients, 41 males, 36 females, with an average age of 42 years; a group B: BMI<24 kg/m2, 63 patients, 38 males, 25 females, with an average age of 67 years, and the age, gender, type of hiatal hernia, score of subjective feeling of symptoms, level of reflux esophagitis were analyzed with the propensity score matching method. Fifty one patients were successfully matched in each group, and the curative effect of surgery was compared between the two groups.ResultsThere was no statistical difference in the type of surgery, intraoperative complications, postoperative complications, and hospital stay between the two groups (P>0.05). The operative time of the group A was significantly longer than that of the group B (P=0.023). There was no statistical difference between the two groups in postoperative recurrence (P=0.741).ConclusionThe operative time in overweight patients is significantly longer than that in the non-overweight patients, but it has no effect on the surgical outcomes and complications.
ObjectivesTo systematically review the association between pretreatment serum ferritin (SF) concentration and prognosis in lung cancer patients.MethodsDatabases including PubMed, EMbase, Web of Science, CNKI, VIP and WanFang Data were electronically searched to identify cohort studies on the relationship between the pretreatment SF concentration and prognosis of lung cancer patients from inception to January, 2020. Literature screening, data extraction and quality evaluation of included studies were independently performed by two reviewers. Then, meta-analysis was conducted by Stata 12.0 software.ResultsA total of 8 cohort studies involving 1 002 lung cancer patients were included. The results of meta-analysis indicated that patients with higher pretreatment SF concentration had poorer overall survival (HR=1.70, 95%CI 1.06 to 2.73, P=0.029) compared with patients with lower pretreatment SF concentration. Subgroup analysis based on the pathological type manifested showed that pretreatment SF concentration only had high prognostic value in small cell lung cancer patients (HR=4.78, 95%CI 2.83 to 8.05, P<0.001).ConclusionsLung cancer patients with high pretreatment SF level have worse overall survival. Pretreatment SF concentration may serve as an independent prognostic factor in lung cancer, especially in small cell lung cancer. Due to the limited quality and quantity of included studies, more prospective well-designed studies are required to verify above conclusions.