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find Author "LI Shengbing" 1 results
  • Effects of Aspart Insulin Thrice Daily Treatment on Plasma Fibroblast Growth Factor-21 Level in Patients with Type 2 Diabetes Mellitus

    【摘要】 目的 探讨预混门冬胰岛素对2型糖尿病(type 2 diabetes mellitus,T2DM)患者血浆成纤维细胞生长因子-21(fibroblast growth factor-21,FGF-21)水平的影响。 方法 2008年2—12月采用酶联免疫吸附试验测定44例正常人及37例采用预混门冬胰岛素治疗前后的T2DM患者的血浆FGF-21水平,分析血浆FGF-21水平与体质量指数(body mass index,BMI)、体内脂肪百分比(FAT%)、腰臀比、血脂、血糖、糖化血红蛋白(hemoglobin A1c, HbA1c)、游离脂肪酸(free fatty acid,FFA)等的关系。 结果 治疗前T2DM组患者血浆FGF-21[(1.79±0.04) μg/L]水平明显高于正常对照组[(1.35± 0.21) μg/L],差异有统计学意义(Plt;0.01)。T2DM组经16周预混人胰岛素类似物(BIAsp 50和BIAsp 30)治疗后FFA、HbA1c、空腹血糖、餐后2 h血糖均降低(Plt;0.01),空腹血浆FGF-21水平降低至(1.33±0.39) μg/L,与治疗前比较差异有统计学意义(Plt;0.01)。相关分析发现T2DM组患者血浆FGF-21水平与BMI呈正相关(r=0.53,Plt;0.01),BMI是影响T2DM患者血浆FGF-21水平的独立相关因素。 结论 预混人胰岛素类似物能有效改善T2DM患者代谢紊乱,同时能显著降低FGF-21水平。【Abstract】 Objective To investigate the effects of treatment with aspart insulin on plasma fibroblast growth factor-21 (FGF-21) levels in patients with type 2 diabetes mellitus (T2DM). Methods From February to December 2008, plasma FGF-21 levels were measured by enzyme-linked immunosorbent assay in 37 patients with T2DM treated with aspart insulin and 44 normal controls. The relationship between plasma FGF-21 levels and body mass index (BMI), percentage of body fat (FAT%), waist-hip ratio (WHR), blood lipid, blood glucose, hemoglobin A1c (HbA1c), and free fatty acid (FFA) was analyzed. Results Before treatment, plasma FGF-21 level was significantly higher in T2DM patients [(1.79±0.04) μg/L] than that in the normal controls [(1.35±0.21) μg/L] (Plt;0.01). After 16 weeks of treatment with premixed human insulin analogues (BIAsp 50 and BIAsp 30), FFA, HbA1c, fasting plasma glucose and 2-hour postprandial blood glucose decreased significantly (Plt;0.01), and fasting plasma FGF-21 level decreased to (1.33±0.39) μg/L which was significantly different from that before treatment (Plt;0.01). Correlation analysis showed that plasma FGF-21 level was positively correlated with BMI (r=0.53,Plt;0.01), which was an independent factor in influencing the FGF-21 level in the patients. Conclusion Aspart insulin treatment can remarkably improve glucose metabolism and significantly decrease the fasting plasma FGF-21 level.

    Release date:2016-09-08 09:26 Export PDF Favorites Scan
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