Objective To review the current condition, test method and progress of the animal model of xeno graft versus host disease(xeno GVHD). Methods The literature review and comprehensive analysis methods were used in this article. Results Implanted immunologic cells, the recepient had the chance of showing host versus graft reaction, GVHD or microchimerism. Now, xeno GVHD could be induced in vivo at small and large animals, it also could be supervised through many ways. Conclusion Chimeric cell is very important to xeno-GVHD animal model. With this model, we can really mimic the immunologic change in vivo after xenotransplantation.
OBJECTIVE To investigate the mechanism of xenotransplantation rejection and the interaction between the immunocytes. METHODS: This review concluded the research achievements and new advances in xenotransplantation based on the relevant experimental data. RESULTS: Transgenic pig technology and novel immunosuppressants were applied to suppress hyperacute rejection and acute vascular rejection respectively. Modulation of T cell and antigen presenting cells and induction of tolerance were taken for the prevention of acute cellular rejection. CONCLUSION: In general, the technology of transgenic pig is relatively mature and effective. The mechanism and prevention of acute vascular rejection and acute cellular rejection should be further investigated.