Objective To evaluate the efficacy of the light cured flowable composite resin and the light cured pit and fissure sealant in the prevention of dental caries in children. Methods EMbase, CBM, The Cochrane Library, PubMed, Web of Science, CNKI, WanFang Data and VIP databases were searched from inception to January 1st, 2017 for randomized controlled trials (RCTs) or quasi-RCTs about the application of the light cured flowable composite resin and the light cured pit and fissure sealants. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, the RevMan 5.3 software was applied to conduct meta-analysis. Results A total of 13 studies were included. The results of meta-analysis showed that the complete retention rate of the light cured flowable composite resin group was higher than that of the light cured pit and fissure sealant group (6 months: RR=1.03, 95%CI 1.00 to 1.06, P=0.03; 12 months: RR=1.09, 95%CI 1.04 to 1.13, P=0.000 3; 24 months: RR=1.22, 95%CI 1.13 to 1.31, P<0.000 01). The incidence of caries of the light cured flowable composite resin group was lower than that of the light cured pit and fissure sealant group (12 months: Peto OR=0.30, 95%CI 0.16 to 0.56,P=0.000 2; 24 months: Peto OR=0.44, 95%CI 0.31 to 0.63, P<0.000 01). Conclusion The light cured flowable composite resin is superior to the light cured pit and fissure sealant in the complete retention and caries prevention. The above conclusions are needed to be verified by more high-quality clinical studies because of the limitation of the quality and follow-up time of studies.
Objective During primary total knee arthroplasty (TKA), anticoagulant drugs are used for prevention of major venous thrombosis of lower limbs, and this often leads to the increase of perioperative blood loss. To retrospectively analyse the impact of low molecular weight heparin on hidden blood loss and transfusion rate after primary TKA by comparing with the use of aspirin. Methods Between October 2007 and August 2009, the clinical data from 286 patients undergoing primary TKA surgery were retrospectively analyzed. In accordance with different anticoagulation methods, the cases were divided into 2 groups, the trial group (n=166) and the control group (n=120). In the trial group, the patients received low molecular weight heparin (4 000-6 000 U/day) from 8-12 hours after TKA for 14 days; there were 27 males and 139 females with an average age of 66.1 years (range, 22-82 years); the body mass index (BMI) was 26.79 ± 3.87; and the locations were the left knee in 99 cases and the right knee in 67 cases with an average disease duration of 4.1 years (range, 1.8-8.6 years). In the control group, the patients received aspirin (150 mg/day) for 14 days; there were 21 males and 99 females with an average age of 64.9 years (range, 40-84 years); the BMI was 27.87 ± 3.62; and the locations were the left knee in 78 cases and the right knee in 42 cases with an average disease duration of 4.9 years (range, 1.5-8.2 years). There was no significant difference in the general data between 2 groups (P gt; 0.05). Results The incisions healed by first intention in all patients. Postoperative deep venous thrombosis occurred in 37 patients of the trial group and in 28 cases of the control group. All the patients were followed up 12-34 months (mean, 21.6 months). There were significant differences in the United States Hospital for Special Surgery (HSS) score of 2 groups between before surgery and after surgery (P lt; 0.05). The hidden blood loss was (40.55 ± 37.75) g/L in the trial group and (32.52 ± 40.13) g/L in the control group, showing significant difference (t=3.387, P=0.001); the dominant blood loss was (24.08 ± 14.63) g/L and (27.91 ± 18.47) g/L respectively, showing no significant difference (t= —1.899, P=0.059). The blood transfusion rates were 40.4% (67/166) in the trial group and 30.0% (36/120) in the control group, showing no significant difference (χ2=2.771, P=0.081); the transfusion volumes were (1.44 ± 4.03) U and (0.97 ± 3.50) U respectively, showing significant difference (t=2.071, P=0.039). Conclusion The low molecular weight heparin has effect on the hidden blood loss after primary TKA, which may increase postoperative blood loss and blood transfusion rate. The changes in hemoglobin should be monitored during the anticoagulant therapy, and the blood volume should be added promptly.
Objective To evaluate the association between coronary heart disease (CHD) and plasma homocysteine level, and to provide additional information for prevention and management of CHD. Methods We searched CBM, CNKI, WanFang, and VIP databases. Case-control studies about the association between CHD and plasma homocysteine level published in China were identified. Meta-analysis was performed using RevMan 4.2 software. Results The result of meta-analysis showed the plasma homocysteine level in the CHD group was higher than that of the control group (WMD=4.88, 95%CI 4.40 to 5.35, Plt;0.000 01), and the loss of safety coefficient was 1 339. Conclusion High plasma homocysteine level is associated with increasing morbidity of CHD.