ObjectiveTo review the disc degeneration models and the current treatment status of calcitonin. MethodsRecent literature concerning the disc degeneration models and the calcitonin treatment of disc degeneration was extensively reviewed and summarized. ResultsDifferent models of disc degeneration have advantages and disadvantages; calcitonin can relieve disc degeneration at different degrees in vitro and in vivo studies. ConclusionDisc degeneration model for the study of disc degeneration mechanism offers a variety of ideas,and the results of calcitonin treatment in the disc degeneration model can provide the basis for future experiments.