west china medical publishers
Author
  • Title
  • Author
  • Keyword
  • Abstract
Advance search
Advance search

Search

find Author "LIXun" 4 results
  • Effects of Signaling Pathway on Development of Hepatocellular Carcinoma

    ObjectiveTo investigate the effects of signaling pathway about the EGFR, MAPK, IKB/NF-κB, PI3K/Akt, WNT/beta-catenin, and the Hedgehog in development of hepatocellular carcinoma(HCC). MethodsThe related literatures about the molecular genetic mechanism of signaling pathways were reviewed. ResultsIn the occurrence and development of HCC, the EGFR, MAPK, IKB/NF-κB, PI3K/Akt, WNT/β-catenin, and Hedgehog signaling pathways not only interweaver with each other complexly, but also interact with each other, and some tumor markers, anticancer genes, proto-oncogenes, and miRNA may have synergistic effects for the occurrence of HCC. ConclusionThe abnormal changes of molecular signaling pathways is a necessary condition for the occurrence and development of tumor, and there is considerable cross-talk and redundancy to many signaling pathways.

    Release date: Export PDF Favorites Scan
  • Acute Pancreatitis Leads to The Reduction of Nitric Oxide Synthase and Vasoactive Intestinal Peptide-Positive Neurons in Rabbit Sphincter of Oddi

    ObjectiveTo investigate the relationship between the changes of nerve cells in sphincter of Oddi and acute pancreatitis. MethodsThe rabbit models of acute pancreatitis were prepared by using sodium taurocholate perfusion. Immunohistochemical method was used to detect the expressions of nitric oxide synthase (NOS) and vasoactive intestinal peptide (VIP) in neurons of the sphincter of Oddi. ResultsIn the control group, (45.83±2.17)% of myenteric neurons were NOS-positive, (52.46±2.47)% of myenteric neurons were VIP positive, and (22.73±1.95)% of myenteric neurons were NOS and VIP double positive. In contrast, (11.26±0.93)% of myenteric neurons were NOS-positive and (28.62±2.83)% of myenteric neurons were VIP positive in SAP group, which were significantly less than those of control group (P < 0.01). ConclusionsThe sphincter of Oddi of normal rabbits is rich in VIP and NOS positive neurons. The significant reduction of NOS-positive and VIP-positive neurons when SAP, which may be the reason of decreased the activities of the sphincter of Oddi.

    Release date: Export PDF Favorites Scan
  • Influence Factors of Pancreatic Cancer: Analysis of 71 Cases

    ObjectiveTo explore the prognostic factors of pancreatic cancer. MethodsClinical data of 71 patients of pancreatic cancer who treated in The First Hospital of Lanzhou University from January 2010 to December 2014 were retrospectively collected to analyze the prognostic factors of pancreatic cancer. ResultsSixty patients of the 71 patients were followed up for 5-36 months, with the median time of 16 months, and the 1, 2, and 3-year cumulative survival rates were 60.6%, 23.9%, and 1.4% respectively. Univariate analysis results showed that, gender (P=0.043), lymph node metastasis (P=0.002), distant metastasis (P=0.000), TNM staging (P=0.000), and peripancreatic invasion (P=0.000) were correlated with the prognosis of pancreatic cancer, that female patients, patients with the presence of lymph node metastasis, distant metastasis, later TNM staging, and peripancreatic invasion had worse prognosis. Cox proportional hazard model results showed that, distant metastasis (P=0.047), TNM staging (P=0.002), and peripancreatic invasion (P=0.016) were prognostic factors of pancreatic cancer, patients with the presence of distant metastasis, later TNM staging, and peripancreatic invasion had poor prognosis. ConclusionDistant metastasis, TNM staging, and peripancreatic invasion were independent prognostic factors of pancreatic cancer.

    Release date: Export PDF Favorites Scan
  • Significance of endoscopic drainage procedures selected to treat acute cholangitis of severe type in elderly patients with chronic respiratory disease

    Objective To investigate the alternatives of different endoscopic drainages for acute cholangitis of severe type (ACST) in elderly patients with chronic respiratory disease. Methods The clinical data of 74 cases of ACST in elderly patients with chronic respiratory disease undergoing 3 kinds of drainages, endoscopic retrograde double biliary stent drainage (D-ERBD), endoscopic retrograde single biliary stent drainage (S-ERBD), or endoscopic nasobiliary drainage (ENBD) in the First Hospital of Lanzhou University from October 2005 to October 2015 were collected to analyze prospectively. Results Compared with preoperative, the white blood cell (WBC), direct bilirubin (DBIL), temperature, and abdominal pain NRS evaluation in 48 h after operation in 3 groups all decreased, the difference was statistically significant (P<0.05). Compared among 3 groups, there were no significant difference among the incidences of postoperative hyperamylasemia, pancreatitis and gastrointestinal hemorrhage (P>0.05). The group of ENBD was more likely to develop pulmonary infection and achieve a secondary treatment than other 2 groups (P<0.05). Totally 5 patients died in 3 groups, with a mortality of 6.76%, but the mortality rates were similar among the 3 groups (P>0.05). The deaths were predominantly caused by multiple organ failure (MOF), 4 cases of which were caused by respiratory failure related to respiratory infection. Conclusion The alternative of endoscopic retrograde double biliary stent drainage (D-ERBD) can not only alleviate cholangitis rapidly, but it can reduce the incidence of aspiration pneumonia.

    Release date:2017-01-18 08:04 Export PDF Favorites Scan
1 pages Previous 1 Next

Format

Content