As one of the hottest artificial intelligence technologies currently, ChatGPT, as one of the hottest artificial intelligence technologies today, plays a significant role in advancing the field of evidence-based medicine, particularly in expanding the sources of original evidence, enhancing the efficiency of evidence acquisition, aiding in shared decision-making between doctors and patients, and promoting education in evidence-based medicine and public science education. Presently, ChatGPT is in its "technological budding phase" and it is crucial to be wary of the risks it brings, such as "evidence contamination", algorithmic black boxes, security vulnerabilities, and the digital divide. To balance the positive effects and potential risks of ChatGPT in the realm of evidence-based medicine, we offer countermeasures and suggestions from the perspectives of ChatGPT's ethical standards, evidence sources, expert verification, and usage norms.