Objectives To investigate the clinical therapeutic effect of tibial boneskin flaps in the repair of infective boneskin defects of the leg. Methods Between February 2000 and March 2005, 68 cases of leg infective wounds with tibial bone and skin defects were treated: 4 cases using free grafting, 64 cases using crossleg or ipsilateral transposition grafting of tibial boneskin flaps so that the tibial support continuity of the affected leg could be reconstructed and the wound could be covered at one stage. The skin flap area ranged from 9 cm×4 cm to 25 cm×12 cm and the bone flap length ranged from 6 cm to 21 cm. Results The flaps were completely survived in 67 of the 68 cases except 1 case which was repaired by fibular boneskin flaps because of the failed blood-vessel anastomosis; the bone flaps were healed in 66 cases,except 1 case which had delayed union of the proximal end through 6month follow-up because tibial bone flap was lengthened, leading to long soft tissue stripping of the proximal end. All the 68 patients were followed up 6 months to 5 years. The leg function and contour weresatisfactory 2 years after operation. Those patients followed up more than 2 years showed normal weight loading walking without obviously abnormal gait, and can engaged in original work. Conclusion On the basis of sufficient antiinfection, the onestage reconstruction of tibial support continuity and the covering of wound by the three methods are suitable for many types of leg bone and skin defects, have a great application value and high successful rate and can retain the affected limb and create the conditions for the functional recovery.