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find Author "MAO Gaoping" 1 results
  • Clinical Comprehensive Therapy of Peutz-Jeghers Syndrome (Report of 71 Cases)

    Objective To explore the clinical comprehensive therapy of Peutz-Jeghers syndrome. Methods From January 2000 to December 2010,71 cases of Peutz-Jeghers syndrome underwent endoscopic polyp resection firstly,and those with unresectable lesions or with severe complications underwent rescue laparotomy. After endoscopic or surgical treatment,the patients took Celecoxib capsules voluntarily for 6 to 9 months under informed consents. All cases were followed up from 6 months to 8 years. Results Twenty-nine patients had familial history of Peutz-Jeghers syndrome among the 71 patients (41 males and 30 females). Sixty-two cases underwent 94 surgeries and intussusception was the most common cause of laparotomy. Sixty-five patients underwent 169 double-balloon endoscopy (DBE) therapies,and a total of 1 714 polyps were resected by DBE polypectomy. The largest major axis of small-bowel polyp was 8 cm. No severe complications occurred after DBE polypectomy except for 3 cases of intestinal perforation. Eight patients took Celecoxib capsule,3 of them were treated more than 6 months,and DBE examination showed the gastrointestinal polyps reduced in number and size. Conclusion The comprehensive treatment (including of endoscopic therapy,operation,and drug intervention) is a safe and effective clinical model to treat Peutz-Jeghers syndrome.

    Release date:2016-09-08 10:37 Export PDF Favorites Scan
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