The traditional paradigm of motor-imagery-based brain-computer interface (BCI) is abstract, which cannot effectively guide users to modulate brain activity, thus limiting the activation degree of the sensorimotor cortex. It was found that the motor imagery task of Chinese characters writing was better accepted by users and helped guide them to modulate their sensorimotor rhythms. However, different Chinese characters have different writing complexity (number of strokes), and the effect of motor imagery tasks of Chinese characters with different writing complexity on the performance of motor-imagery-based BCI is still unclear. In this paper, a total of 12 healthy subjects were recruited for studying the effects of motor imagery tasks of Chinese characters with two different writing complexity (5 and 10 strokes) on the performance of motor-imagery-based BCI. The experimental results showed that, compared with Chinese characters with 5 strokes, motor imagery task of Chinese characters writing with 10 strokes obtained stronger sensorimotor rhythm and better recognition performance (P < 0.05). This study indicated that, appropriately increasing the complexity of the motor imagery task of Chinese characters writing can obtain stronger motor imagery potential and improve the recognition accuracy of motor-imagery-based BCI, which provides a reference for the design of the motor-imagery-based BCI paradigm in the future.
目的 探讨ATP结合盒转运子A1（ABCA1）基因R219K多态性与新疆维吾尔族和汉族冠心病及血脂的相关性。 方法 收集2006年12月－2008年5月住院及门诊患者中无血缘关系的维吾尔族、汉族为研究对象。冠心病组377例，其中维吾尔族199例，汉族178例；对照组178例，其中维吾尔族83例，汉族95例。用聚合酶链式反应限制性片段长度多态性方法，检测维吾尔族和汉族冠心病组及对照组ABCA1基因R219K多态性，并比较不同基因型间血脂水平。 结果 ABCA1基因R219K多态性K等位基因频率在维吾尔族冠心病组和对照组间分布差异有统计学意义（P＜0.05）。维吾尔族对照组中载脂蛋白A水平在KR型高于KK型，汉族冠心病组中低密度脂蛋白胆固醇水平在KR型高于KK型，差异有统计学意义（P＜0.05），但不具有临床意义。不同基因型间的其余血脂水平差异无统计学意义（P＞0.05）。 结论 ABCA1基因R219K多态性K等位基因频率与维吾尔族冠心病相关，K等位基因可能降低其发病风险；ABCA1 R219K多态性等位基因频率在维吾尔族和汉族间无差异，且对维吾尔族、汉族血脂水平无明显影响。
ObjectiveTo explore the clinical significance of detecting serum intact parathyroid hormone (iPTH) and drainage fluid parathyroid hormone (dPTH) after thyroidectomy in forecasting parathyroid function.MethodsThe clinical data of 95 thyroidectomy patients in the same treatment group from March 2018 to September 2018 were retrospectively analyzed, which in the Department of Thyroid-Breast Surgery, the Second Affiliated Hospital of Kunming Medical University. According to the surgical method, the patients were divided into 3 groups: isthmus and unilateral thyroidectomy (partial resection group, n=33), total thyroidectomy (total resection group, n=33) and total thyroidectomy and central lymph node excision (radical resection group, n=29). The negative pressure drainage tube was placed in the operative area. The iPTH and serum calcium were detected before and the first day after operation. The dPTH was detected in the first day and the second day after operation. Serum calcium, iPTH and dPTH were statistically analyzed.ResultsThere were no significant differences in operative time, hospital stay and blood loss between the total resection group and the radical resection group (P>0.05), but the partial resection group were all less than the other two groups (P<0.01). On the first day after operation, the iPTH in the three groups were lower than that before operation, and the iPTH was significantly decreased in the total resection group and the radical resection group, with statistically significant difference (P<0.05). The dPTH in the three groups were significantly increased on the first and second day after operation (P<0.05), but there was no statistically significant difference between the three groups (P>0.05). There was no statistically significant difference in serum calcium between the three groups on the first day after operation (P>0.05).ConclusionsThe levels of iPTH, dPTH and serum calcium after thyroidectomy can comprehensively forecast the parathyroid function. Preventive calcium supplementation can reduce the occurrence of postoperative symptomatic hypocalcemia, which is conducive to the recovery of parathyroid function.