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find Author "MU Hua" 1 results
  • Effect of estrogen on the expression of pigment epithelium derived factor in cul tured retinal Müller cells under the anoxic condition.

    Objective: To observe the effect of estrogen on the expr ession of pigment epithelium derived factor (PEDF) in cultured retinal Muuml;ller cells under the anoxic condition. Methods:After the anoxic retinal Muuml;ll er cells were tre ated with estrogen (E2) with the concentration of 10-6、10-5 and 10-7 mmol/L, t he level of expression of PEDF mRNA and the protein was detected by reverse tran scriptionpolymerase chain reaction and Western blotting analysis. Results:Th e expression of PEDF mRNA and protein decreased 24 hours after anoxia. E2 with t he concentration of 10-5 and 10-6 mmol/L inhibited the decrease of expression of PEDF mRNA and protein induced by anoxia, which related to the concentration of E2. Conclusion:strogen can regulate the expression of PEDF, which ma y play an important role in the regulation of retinal neovascularization.

    Release date:2016-09-02 05:48 Export PDF Favorites Scan
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