Objective To summarize the advantages and complications of implantation of venous access port via axillary vein in the operation of breast cancer, and to explore the countermeasures against the complications. Methods A total of 40 female patients with breast cancer were enrolled in this observational study between January 2011 and September 2014. They were aged from 32 to 62 years with a mean of 49.3 years. The time for implantation, catheter life, reasons for port removal and complications were evaluated. Results The average time for implantation was 23.3 minutes. The catheter life ranged from 142 to 917 days with a mean of 395 days. Four patients (10%) had port-related complications including 2 cases of pocket infection and 2 of catheter dysfunction. Thirty-one ports were removed for termination of chemotherapy, and four were removed for complications. Conclusions It is simple and time-saving to implant venous access port via axillary vein in the operation of breast cancer. The incidence of pocket infection is high, and is expected to be reduced by choosing appropriate cases and taking strict aseptic norms.