Based on the guidelines of the diagnostic test systematic review, this study elaborated the statistical processing of the pooling of data detailed in the systematic review of diagnostic test, discussed the methods for identification and handling of the heterogeneity, evaluated the advantages and disadvantages of the index of the accuracy in diagnostic tests, and proposed the identification method of the publication bias. It also took the data from the published article entitled “Diagnostic Value of ProGRP and NSE for Small Cell Lung Cancer: A Meta-Analysis” as an example for analysis and illustration, which presented clearly the data processing and interpretation of the systematic review of diagnostic test, in order to provide references for clinical researchers to study and conduct the systematic review of diagnostic test.
Objective To study the value of the clinical application of stereography and measurement of liver volume in cirrhotic patients with portal hypertension. Methods By use of the personal computer and the software of threedimensional reconstruction and measurement system of liver faultage photograph, the liver volume in vivo was successfully measured and the threedimensional image of the liver rebuilt in 46 posthepatitic cirrhotics who were selected for orthotopic liver transplantation and in 30 noncirrhotic controls, and comparison with the reference volume of recipient liver was obtained by means of water deplacement after transplantation. Results The liver volume of cirrhotic patients with portal hypertension measured by software and water deplacement was (983.33±206.11) cm3, and (904.93±209.56) cm3 respectively. Comparison by means of linear regression analysis between volume measurement on threedimensional reconstruction software and reference volume showed a nearly ideal correlation coefficient(r=0.969,P＜0.01), the average error was 8.66%.The average of liver volume in controls was (1287.00±96.18) cm3, and was positively correlated to the height，weight and body surface area (r=0.845,0.833,0.932 respectively,P＜0.01)，and was different from that of cirrhotics. Liver volume of cirrhoitic patients with portal hypertension was related to their ChildPugh classification. The liver volume of patients in Child C group was significantly smaller than that of patients of Child B group, and was significantly correlated with Alb （r=0.496, P＜0.01） and TBIL（r=-0.493, P＜0.01）,PT(r=-0.517, P＜0.01), but was not significantly correlated with ALT（r=0.206，Pgt;0.05）,portal pressure（r=-0.093，P=0.539） and portosystemic shunt index (r=0.044，P=0.769). Conclusion The volume measurement of the liver by the threedimensional software is relatively accurate. Liver volume of cirrhotic patients with portal hypertension was significantly related to their liver function,and can reflect the liver reserve function.
To study project of simpl icity and util ity for screw-plate system by pedicle of atlanto-axis mani pulatively hand by X-ray film and CT to prove the one success rate of putting screws. Methods Formulate personal program was used in operation by image save transmission of X-ray film and CT during January 2002 and September 2006 in 31 patients. There were 18 males and 13 femals, aged from 23 to 61 years old with an average age of 43.5 years. Putting screw points bypedicle of atlas were measured: left (19.93 ± 1.32) mm, right (19.16 ± 1.30) mm; putting screw obl iquity angle to inside by pedicle of atlas: left (23.72 ± 2.09)°, right (23.35 ± 1.91)°; putting screw obl iquity angle to side of head by pedicle of atlas: (9.00 ± 1.20)°. Screw points by pedicle of axis: left (13.14 ± 0.82) mm right (13.85 ± 0.79) mm; putting screw obl iquity angle to inside by pedicle of axis: left (24.52 ± 1.26)°, right (20.42 ± 1.42)°; putting screw obl iquity angle to side of head by pedicle of axis: (25.00 ± 3.00)°. The domestic location toward speculum was employed in operation and putting screw points and angles were formulated by X-CT program. The pedicle screws of suitable diameter and length were of exception and screws into pedicle of atlanto-axis were put by hand. Results Pain of the greater occipital nerve occurred in 2 patients after operation and was fully recovered by treatment 1 month after operation. The lateral cortical bone of pedicle was cut by 2 screws, but the spinal cord and vertebral artery were fine. The atlas and the fracture of odontoid process of axis were completely replaced in X-ray films of all patients 1 day after operation.The position relation of lag screw and vertebral artery or spinal cord was very good in CT sheets. All cases were followed up with an average of 10.5 months during 9 months to 5 years and 4 months, and obtained atlantoaxial arthrodesis. The breakage of screw and plate was not found in all cases. According to JOA score standard, 16 cases were excellent, 12 were good, 2 were fair, 1 was poor, and the excellent and good rate was 90.32% . Conclusion The personal design and cl inical appl ication of X-ray films and CT sheets are of great significance to screw-plate system by pedicle of atlanto-axis because of simpl ification of designs and methods and better personal ity.
The experiment performed on domestic pig, was designed to investigate the architecture of the stretching skin and the effect of tension traction on the wound closure. An 7 cm x 3.5 cm was drawn at a standard position. Drawing horizontal and vertical lines on the traction area, points of 1 cm apart were tattooed on the lines. A traction force measuring device was used to draw the wound edges together. Measurements of the distances between the points were made. An 7 cm x 10 cm wound was made on identical sites of each hind leg. In the experiment the traction tension was applied on the edges of wound immediately after the wound debridement. The results showed the stretched distance in the two areas was 5-7 times the width of the wound. The gain of skin from traction was 61-89 percent in the width of the wound. The wounds from traction five days could be closed 5 days after traction. It was concluded that the skin which could be used for traction was abundant. Wound closure with the skin traction technique had many advantages, such as rapid decreasing the size of wound and early closing of wound.
Abstract An animal experiment had been conducted for the purpose to find out the possibility of application of instantaneous sustained limited expansion (ISLE). A total of 54 skin defects in 9 pigs were obtained and were divided into two groups. One group of the pigs were subjected to instantaneous sustained limited expansion, the others, as the control group, just received the tension suture. At the same time the blood supply of the skin was measured by laser doppler flowmeter (LDF). It was showed that microcirculatory perfusion of the ISLE group was considerably better than that of the control. Inaddition, the correlation between the blood flow of the skin and the expanding pressure, as well as the pathologic changes of the skin were discussed.
ObjectivesTo understand the quantitative measurement tools for active aging and compare the index construction, applicability and application of different tools domestically and abroad, so as to provide a scientific basis for the formulation and improvement of localized measurement tools for active aging.MethodsWe performed electronical searches on PubMed, Web of Science, Elsevier, CNKI, WanFang Data, VIP, and websites of WHO, European Commission, United Nations Economic Commission for Europe from April 2002 to November 2019. Two reviewers independently screened literature and extracted data according to inclusion and exclusion criteria, and conducted a qualitative analysis and comparison of the obtained measurement tools.ResultsA total of 36 researches were included, which involved 9 original active aging quantitative measurement tools. Specifically, 3 were from Thailand, 2 were from China, 1 was from the European Union, Russia, Australia and Finland, respectively. There were 2 to 3 dimensions of the tools, 3 to 10 items of primary measurement targets, and 11 to 177 items of measurement indicators. The construction of the dimension and first-level measurement goals were mainly based on the three pillars of health, participation, and security which composed WHO’s policy framework. The indicators of tools had measured the health, participation, and security targets except for the AAQ-CHN (2012) and AAL-Thai (2016) tools. Five age-specific indicators of the use of electronic information technology equipment, voluntary services, participation in political activities, access to health care services, and lifelong learning habits appeared in the EU tool. The AAI-EU's empirical applications and related 20 studies had been published mainly in Europe, Asia, and the Americas. AAI-Thai (2006) and AAI-Thai (2014) were used in empirical researches in Asia and China, respectively, and the 3rd and 4th studies were published.ConclusionsThe indicators' design of AAI-EU (2012) has the most contemporary characteristics, the most confirmatory research and widest application. The development of Chinese localized quantitative measurement tools should take advantage of the EU and other representative measurement tools.
The COSMIN-RoB checklist includes three sections with a total of 10 boxes, which is used to evaluate risk of bias of studies on content validity, internal structure, and other measurement properties. COSMIN classifies reliability, measurement error, criteria validity, hypothesis testing for construct validity, and responsiveness as other measurement properties, which primarily focus on the quality of the (sub)scale as a whole, rather than on the item level. Among the five measurement properties, reliability, measurement error and criteria validity are the most widely used in the studies. Therefore, this paper aims to interpret COSMIN-RoB checklist with examples to guide researchers to evaluate the risk of bias of the studies on reliability, measurement error and criteria validity of PROMs.
Measurement properties studies of patient-reported outcome measures (PROMs) aims to validate the measurement properties of PROMs. In the process of designing and statistical analysis of these measurement properties studies, bias will occur if there are any defects, which will affect the quality of PROMs. Therefore, the COSMIN (consensus-based standards for the selection of health measurement instruments) team has developed the COSMIN risk of bias (COSMIN-RoB) checklist to evaluate risk of bias of studies on measurement properties of PROMs. The checklist can be used to develop systematic reviews of PROMs measurement properties, and for PROMs developers, it can also be used to guide the research design in the measurement tool development process for reducing bias. At present, similar assessment tools are lacking in China. Therefore, this article aims to introduce the primary contents of COSMIN-RoB checklist and to interpret how to evaluate risk of bias of the internal structure studies of PROMs with examples.
Dyspnea is the most common symptom in patients with acute heart failure syndrome (AHFS), and relieving dyspnea is an important goal in clinical practice, clinical trials and new drug regulatory approval. However, in clinical and scientific research, there is still no consensus on how to evaluate dyspnea, and there is still a lack of unified measurement methods. This article introduces the pathophysiological mechanism of dyspnea in acute heart failure, the measuring time of dyspnea, the posture of patients during measurement, the measuring conditions, and the common measurement methods of dyspnea in clinical trials and their advantages and disadvantages, so as to provide references for the selection of measurement methods of dyspnea in clinical trials of acute heart failure.
The COSMIN community updated the COSMIN-RoB checklist on reliability and measurement error in 2021. The updated checklist can be applied to the assessment of all types of outcome measurement studies, including clinician-reported outcome measures (ClinPOMs), performance-basd outcome measurement instruments (PerFOMs), and laboratory values. In order to help readers better understand and apply the updated COSMIN-RoB checklist and provide methodological references for conducting systematic reviews of ClinPOMs, PerFOMs and laboratory values, this paper aimed to interpret the updated COSMIN-RoB checklist on reliability and measurement error studies.