Objective To summarize and analyze the different modality on molecular imaging of tracking and monitoring for islet transplantation．Methods The current domestic and foreign reports on molecular imaging of islet transplantation were reviewed．Results Magnetic resonance imaging has high sensitivity，high spatial resolution，no ionizing radiation，is clinically applicable，and could be used of real-time MR-guided injections，but can’t discriminate between liver and dead cells，difficult to do in patients with liver iron overload．Nuclear molecular imaging only displays liver cells generate signal，is clinically applicable，but disadvantage is genetic manipulation，ionizing radiation，no anatomical information，low spatial resolution．The advantage of in vivo optical imaging is only liver cells generate signal，widely available，no ionizing radiation，and the disadvantage is genetic manipulation，not clinically applicable，low spatial resolution．Conclusions Islet imaging using magnetic resonance，nuclear molecular imaging，in vivo optical imaging，or multimodal imaging of microencapsulated islets may provide us with a direct means to interrogate islet cell distribution，survival，and function．Multimodal imaging of microencapsulated islets may be best way for tracking and monitoring in the future．
ObjectiveTo investigate researches on pancreatic neoplasms and molecular imaging in recent five years and provide reference information for the majority of professionals in deep research. MethodsBibliographies from research literature of pancreatic neoplasms and molecular imaging in recent five years in PubMed database were downloaded. The publication years, journals, countries of publication, the first authors and the frequency of MJMEs were counted by Bicomb 2.0 software. The affiliations were analyzed artificially. MJMEs appeared no less than two times were intercepted as high frequency ones and the high frequency MJMEs co-occurrence matrix were formed. SPSS 22.0 statistical software were applied for clustering analysis with matrix, then to get the topic hotspots. ResultsA total of 28 literatures were screened out. The data of research trend, journals, research degree of countries were acquired. The number of high frequency MJMEs were 20 and among which 5 research hotspots were clustered. ConclusionsResearches on pancreatic neoplasms and molecular imaging are mainly in terms of therapy and genetics, diagnosis and metabolism, radionuclide imaging, pharmacology and pathology.