目的：分析口咽部B细胞来源非霍奇金淋巴瘤(NHL)的CT表现、特征，初步探讨不同病理类型B细胞来源NHL的CT表现特点，为临床诊断和治疗提供更为准确的信息。方法：对18例经病理证实的口咽部B细胞来源非霍奇金淋巴瘤的CT表现进行回顾性分析。结果：18例中，弥漫大B细胞淋巴瘤13例，占72.2%(13/18)，滤泡性淋巴瘤3例，占16.7%(3/18)，套细胞淋巴瘤1例，占5.6%(1/18)，结外边缘区淋巴瘤(MALT淋巴瘤)1例，占5.6%(1/18)。病变分布为：扁桃体NHL9例(弥漫大B细胞淋巴瘤8例、套细胞淋巴瘤1例)；舌根8例(弥漫大B细胞淋巴瘤5例、滤泡性淋巴瘤3例)；软腭1例，为结外边缘区淋巴瘤(MALT淋巴瘤)。18例病变均表现为肿块型。同时有淋巴结受累者12例(66.7%)，其中双侧受累者3例。结论：口咽B细胞来源NHL多发生于扁桃体及舌根。病理类型以弥漫大B细胞淋巴瘤为主，主要表现为肿块。 CT对于B细胞来源NHL的鉴别诊断和病变范围的判断具有重要作用。
Objectives To evaluate the expression and clinical significance of COX-2 in gastric carcinoma. Methods Such databases as PubMed, CNKI, WanFang Data and VIP were searched for the studies on the association between COX-2 and gastric carcinoma from inception to January 2017. Two researchers independently screened literature, extracted data and evaluate the risk of bias of included studies. RevMan 5.3 software were used to analyze the data. Results Eleven case-control studies involving 1 366 patients were included. The results of meta-analysis showed that, there were significant differences of COX-2 expression in the following comparisons: gastric carcinoma vs. normal esophageal tissues (RR=1.69, 95%CI 1.39 to 2.06, P<0.000 01), with serosa invasivevs. without serosa invasive (RR=1.37, 95%CI 1.14 to 1.66, P=0.001), clinical stages Ⅰ-Ⅱ vs. clinical stages Ⅲ-Ⅳ (RR=0.78, 95%CI 0.69 to 0.90, P=0.000 3), as well as lymph node metastasis vs. non-lymph node metastasis (RR=1.48, 95%CI 1.34 to 1.63, P<0.000 01). While no significant difference was found between well/general differentiation group and poorly differentiation group (RR=0.84, 95%CI 0.51 to 1.38,P=0.48). Conclusion COX-2 expression is associated with depth of invasion, clinical stage and lymph node metastasis, which prompts that COX-2 may play an important role in the occurrence and development of gastric carcinoma. Due to limited quality and quantity of the included studies, more high quality studies are needed to verify above conclusion.